Evidence map›Paper›PMID 36557677›Full record

ReviewMicroorganisms2022

Fecal Microbiota Transplantation and Other Gut Microbiota Manipulation Strategies.

Gianluca Quaranta, Alessandra Guarnaccia, Giovanni Fancello, Chiara Agrillo, Federica Iannarelli, Maurizio Sanguinetti, Luca Masucci

Abstract readReview
In one paragraph

Review in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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  7. Next-Generation Probiotics in Allergy Therapy: Scientific Evidence and Clinical Applications.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gianluca QuarantaDepartment of Laboratory and Infectious Sciences, A. Gemelli University Hospital IRCCS, 00168 Rome, Italy.
Alessandra GuarnacciaDepartment of Laboratory and Infectious Sciences, A. Gemelli University Hospital IRCCS, 00168 Rome, Italy.ORCID 0000-0001-7290-8761
Giovanni FancelloDepartment of Laboratory and Infectious Sciences, A. Gemelli University Hospital IRCCS, 00168 Rome, Italy.
Chiara AgrilloDepartment of Laboratory and Infectious Sciences, A. Gemelli University Hospital IRCCS, 00168 Rome, Italy.ORCID 0000-0002-7120-7274
Federica IannarelliDepartment of Laboratory and Infectious Sciences, A. Gemelli University Hospital IRCCS, 00168 Rome, Italy.
Maurizio SanguinettiDepartment of Laboratory and Infectious Sciences, A. Gemelli University Hospital IRCCS, 00168 Rome, Italy.ORCID 0000-0002-9780-7059
Luca MasucciDepartment of Laboratory and Infectious Sciences, A. Gemelli University Hospital IRCCS, 00168 Rome, Italy.ORCID 0000-0002-8358-6726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota is composed of bacteria, archaea, phages, and protozoa. It is now well known that their mutual interactions and metabolism influence host organism pathophysiology. Over the years, there has been growing interest in the composition of the gut microbiota and intervention strategies in order to modulate it. Characterizing the gut microbial populations represents the first step to clarifying the impact on the health/illness equilibrium, and then developing potential tools suited for each clinical disorder. In this review, we discuss the current gut microbiota manipulation strategies available and their clinical applications in personalized medicine. Among them, FMT represents the most widely explored therapeutic tools as recent guidelines and standardization protocols, not only for intestinal disorders. On the other hand, the use of prebiotics and probiotics has evidence of encouraging findings on their safety, patient compliance, and inter-individual effectiveness. In recent years, avant-garde approaches have emerged, including engineered bacterial strains, phage therapy, and genome editing (CRISPR-Cas9), which require further investigation through clinical trials.

Indexed as

dietengineered bacteriaeubiosisFMTgut microbiota modulationpersonalized medicinephagesprebioticsprobiotics

Identifiers

PMID36557677
PMCPMC9781458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.