Evidence map›Paper›PMID 36557266›Full record

ArticleMetabolites2022

Lipidomics and Transcriptomics Differ Liposarcoma Differentiation Characteristics That Can Be Altered by Pentose Phosphate Pathway Intervention.

Zhengqing Song, Shuaikang Wang, Lili Lu, Jingshen Xu, Qiwen Zhou, Weiqi Lu, Hanxing Tong, Yong Zhang, Wenshuai Liu, Zhiming Wang and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Zhengqing SongDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.ORCID 0000-0001-5622-9021
Shuaikang WangDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Lili LuDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Jingshen XuDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Qiwen ZhouDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Weiqi LuDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Hanxing TongDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Yong ZhangDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Wenshuai LiuDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Zhiming WangDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Wei LiDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Yang YouDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Chenlu ZhangDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Xi GuoDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Rongkui LuoDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Yingyong HouDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Chunmeng WangDepartment of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Yuexiang WangInstitute of Nutritional and Health Science, Chinese Academy of Sciences, Shanghai 200031, China.
Lei SunDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
He HuangDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.ORCID 0000-0002-2394-0877
Yuhong ZhouDepartment of Medical Oncology, Biotherapy Center, Department of General Surgery, Department of Pathology, Zhongshan Hospital, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200032, China.
Fudan University · CNChinese Academy of Sciences · CNFudan University Shanghai Cancer Center · CN

Funding

National Key R&D Program of China 2019YFA0801900National Key R&D Program of China 2020YFA0803800National Key R&D Program of China 2021YFA0805100National Natural Science Foundation of China 92057115Shanghai Sailing Program 20YF1402600
6 · The paper itself

Abstract

Liposarcoma (LPS) is a rare and heterogeneous malignancy of adipocytic origin. Well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS) are two of the most common subtypes, showing similar genetic characterizations but distinct biological behaviors and clinical prognosis. Compared to WDLPS, DDLPS is more aggressive and has the potential of metastasis, as the malignant adipocytic tumor's metabolic changes may have taken place during the tumorigenesis of LPSs. Therefore, to investigate the lipid alterations between the two subtypes, high-resolution liquid chromatography tandem mass spectrometry (LC-MS/MS) based untargeted lipidomic analysis was performed onto LPS tissues from 6 WDLPS and 7 DDLPS patients. The lipidomic analysis showed the upregulated phosphatidylcholines and phosphoethanolamines in DDLPS, and the upregulated triglycerides and diglycerides in WDLPS, which might be due to the uncompleted adipocytic dedifferentiation leading to such tumorigenesis. Such a finding was also confirmed by the similarity comparison of two LPS subtypes to the transcriptome of stromal vascular fraction at different differentiation stages. Transcriptomic analysis also demonstrated that metabolic pathways including the pentose phosphate pathway (PPP) were upregulated in WDLPS compared to DDLPS. Therefore, the cell line LPS853 was treated with the PPP inhibitor 6-aminonicotinamide ex vivo and the proliferation and invasion of LPS853 was significantly promoted by PPP inhibition, suggesting the potential role of PPP in the development and differentiation of LPS. In conclusion, this study described the altered lipid profiles of WDLPS and DDLPS for the first time, revealing the different differentiation stages of the two subtypes and providing a potential metabolic target for LPS treatment.

Indexed as

adipogenic differentiationlipidomicsliposarcomapentose phosphate pathwaytranscriptomics

Identifiers

PMID36557266
PMCPMC9783184
OpenAlexW4311728673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.