Evidence map›Paper›PMID 36557201›Full record

ArticleMetabolites2022

Fractional Gluconeogenesis: A Biomarker of Dietary Energy Adequacy in a Rat Brain Injury Model.

Casey C Curl, Anika Kumar, Austin J Peck, Jose A Arevalo, Allison Gleason, Robert G Leija, Adam D Osmond, Justin J Duong, Benjamin F Miller, Michael A Horning and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Altered glucose kinetics occurs with aging: a new outlook on metabolic flexibility.American journal of physiology. Endocrinology and metabolism · 2024
    Article
  2. Underfeeding Alters Brain Tissue Synthesis Rate in a Rat Brain Injury Model.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Casey C CurlDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-5772-7604
Anika KumarDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Austin J PeckDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Jose A ArevaloDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Allison GleasonDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-1069-8356
Robert G LeijaDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-7862-293X
Adam D OsmondDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Justin J DuongDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Benjamin F MillerAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Michael A HorningDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-3936-113X
George A BrooksDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
University of California, Berkeley · USOklahoma Medical Research Foundation · US

Funding

Aging Mitochondrial Fragmentation and Metabolic InflexibilityR01AG059715 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI BROOKS, GEORGE AUSTIN · 2018 to 2022
$3.0M
NIA NIH HHS R01 AG059715Pac-12 Athletic Association CAL-Brooks-17-02UC Berkeley Center for Research and Education on Aging (CREA) 001
6 · The paper itself

Abstract

Patients treated for traumatic brain injury (TBI) are in metabolic crises because of the trauma and underfeeding. We utilized fractional gluconeogenesis (fGNG) to assess nutritional adequacy in ad libitum-fed and calorically-restricted rats following TBI. Male Sprague-Dawley individually housed rats 49 days of age were randomly assigned into four groups: ad libitum (AL) fed control (AL-Con, sham), AL plus TBI (AL+TBI), caloric restriction (CR) control (CR-Con, sham), and CR plus TBI (CR+TBI). From days 1-7 animals were given AL access to food and water containing 6% deuterium oxide (D

Indexed as

D2OfastingglycemiametabolismTBItracer

Identifiers

PMID36557201
PMCPMC9781857
OpenAlexW4309989515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.