ArticleMedicina (Kaunas, Lithuania)2022
Peri-Neural Invasion Is an Important Prognostic Factor of T2N0 Oral Cancer.
Article in Medicina (Kaunas, Lithuania), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Article
- MRI radiomics-based predictive modeling for risk stratification and prognostication in oral tongue carcinoma.Frontiers in oncology · 2026Article
- MRI-based tumor signatures as prognostic biomarkers in oral tongue squamous cell carcinoma.Frontiers in oncology · 2026Article
- Article
- Clinicopathologic Predictors of Survival Following Oral Cancer Surgery: A Retrospective Cohort Study.Cancers · 2025Article
- Review
- Review
- Risk Stratification in Oral Cancer: A Novel Approach.Frontiers in oncology · 2022Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
MATERIALS AND
methodsFrom January 2012 to December 2017, the data of 166 pathologically proven T2N0 oral cancer patients proved by radical surgery were retrospectively collected. The clinical and pathologic factors including age, gender, tumor differentiation grade, perineural invasion (PNI), angiolymphatic invasion (ALI), margin status, and adjuvant therapy were analyzed by univariate and multivariate analysis to determine their association with disease-specific survival (DSS), and disease-free survival (DFS), which were calculated by Kaplan-Meier method.
resultsAfter median follow up time of 43.5 months, overall 3-year rates of DSS and DFS were 86.1% and 80.1% respectively for our 166 patients. Univariate analysis showed that the 3-year DSS of 90.8% for PNI negative patients was significantly better than DSS of 57.0% for PNI positive patients (
conclusionPNI was an independent prognostic factor for T2N0 oral cancer patients. Adjuvant chemotherapy and radiotherapy may benefit the survival of this specific disease entity, but further investigations are needed to elucidate the optimal regimen.
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