ArticleLife (Basel, Switzerland)2022
Age-Dependent Decline in Common Femoral Artery Flow-Mediated Dilation and Wall Shear Stress in Healthy Subjects.
Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Proximal plaque cap morphology in femoropopliteal occlusion affects the primary patency of endovascular therapy: a CT angiography cohort study.La Radiologia medica · 2026Article
- Association of atherosclerotic cardiovascular disease risk stratification with carotid wall shear stress as measured by vector flow mapping: a study of a Chinese population.Quantitative imaging in medicine and surgery · 2026Article
- Effect of breaking up sitting with regular active breaks on glucose management and vascular function in adults with type 1 diabetes who use hybrid closed-loop insulin delivery systems: a randomised crossover trial protocol.BMJ open sport & exercise medicine · 2026Article
- Feasibility of high-resolution flow-mediated dilation using a 24-MHz probe to assess endothelial dysfunction: comparison of hypertensive and normotensive groups.Ultrasonography (Seoul, Korea) · 2025Article
- Variability of flow-mediated dilation across lower and upper limb conduit arteries.European journal of applied physiology · 2024Article
- Vascular Diseases: Etiologic, Diagnostic, Prognostic, and Therapeutic Research.Life (Basel, Switzerland) · 2023Article
- Vascular aging and cardiovascular disease: pathophysiology and measurement in the coronary arteries.Frontiers in cardiovascular medicine · 2023Review
- Leukocyte telomere length and mitochondrial DNA copy number associate with endothelial function in aging-related cardiovascular disease.Frontiers in cardiovascular medicine · 2023Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Femoral artery (FA) endothelial function is a promising biomarker of lower extremity vascular health for peripheral artery disease (PAD) prevention and treatment; however, the impact of age on FA endothelial function has not been reported in healthy adults. Therefore, we evaluated the reproducibility and acceptability of flow-mediated dilation (FMD) in the FA and brachial artery (BA) (n = 20) and performed cross-sectional FA- and BA-FMD measurements in healthy non-smokers aged 22−76 years (n = 50). FMD protocols demonstrated similar good reproducibility. Leg occlusion was deemed more uncomfortable than arm occlusion; thigh occlusion was less tolerated than forearm and calf occlusion. FA-FMD with calf occlusion was lower than BA-FMD (6.0 ± 1.1% vs 6.4 ± 1.3%, p = 0.030). Multivariate linear regression analysis indicated that age (−0.4%/decade) was a significant independent predictor of FA-FMD (R2 = 0.35, p = 0.002). The age-dependent decline in FMD did not significantly differ between FA and BA (pinteraction agexlocation = 0.388). In older participants, 40% of baseline FA wall shear stress (WSS) values were <5 dyne/cm2, which is regarded as pro-atherogenic. In conclusion, endothelial function declines similarly with age in the FA and the BA in healthy adults. The age-dependent FA enlargement results in a critical decrease in WSS that may explain part of the age-dependent predisposition for PAD.
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