Evidence map›Paper›PMID 36556369›Full record

ArticleLife (Basel, Switzerland)2022

Association of TYR SNP rs1042602 with Melanoma Risk and Prognosis.

Arrate Sevilla, Ana Sánchez-Diez, Sofía Cobo, Neskuts Izagirre, Conrado Martinez-Cadenas, Rosa M Martí, Teresa Puértolas, Blanca de Unamuno, José Bañuls, Rosa Izu and 4 more

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Human recombinant tyrosinase destabilization caused by the double mutation R217Q/R402Q.Protein science : a publication of the Protein Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arrate SevillaDepartment of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), 48940 Leioa, Spain.ORCID 0000-0002-4860-3359
Ana Sánchez-DiezDepartment of Dermatology, Basurto University Hospital, 48013 Bilbao, Spain.
Sofía CoboDepartment of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), 48940 Leioa, Spain.ORCID 0000-0002-3170-3863
Neskuts IzagirreDepartment of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), 48940 Leioa, Spain.ORCID 0000-0002-3345-9825
Conrado Martinez-CadenasDepartment of Medicine, Jaume I University of Castellon, 12071 Castellon, Spain.
Rosa M MartíDepartment of Dermatology, Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain.ORCID 0000-0001-6866-6114
Teresa PuértolasOncology Department, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain.
Blanca de UnamunoDepartment of Dermatology, Hospital Universitario de La Fe, 46026 Valencia, Spain.
José BañulsDermatology Department, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), 03010 Alicante, Spain.ORCID 0000-0002-0990-7608
Rosa IzuBiocruces-Bizkaia Health Research Institute, 48903 Barakaldo, Spain.
Jesús GardeazabalBiocruces-Bizkaia Health Research Institute, 48903 Barakaldo, Spain.
Aintzane AsumendiBiocruces-Bizkaia Health Research Institute, 48903 Barakaldo, Spain.ORCID 0000-0002-2156-2323
María D BoyanoBiocruces-Bizkaia Health Research Institute, 48903 Barakaldo, Spain.ORCID 0000-0001-6051-1054
Santos AlonsoDepartment of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), 48940 Leioa, Spain.ORCID 0000-0003-0221-4048

Funding

Basque Government KK2017-041Basque Government KK2020-00069H2020 H2020-ESCEL JTIMinistry of Economy, Industry and Competitiveness PCIN-2015-241University of the Basque Country GIU17/066
6 · The paper itself

Abstract

Cutaneous melanoma is the most aggressive of skin tumors. In order to discover new biomarkers that could help us improve prognostic prediction in melanoma patients, we have searched for germline DNA variants associated with melanoma progression. Thus, after exome sequencing of a set of melanoma patients and healthy control individuals, we identified rs1042602, an SNP within

Indexed as

biomarkermelanomaprognosisrisktyrosinase (TYR)

Identifiers

PMID36556369
PMCPMC9785037

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.