ReviewJournal of personalized medicine2022
Cognitive Impairment after Post-Acute COVID-19 Infection: A Systematic Review of the Literature.
Review in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Definitions and symptoms of the post-COVID syndrome: an updated systematic umbrella review.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- [Cognition and Long COVID: A PRISMA Systematic Review of Longitudinal Studies].Revista de neurologia · 2025Pooled it
- Research evidence on the management of the cognitive impairment component of the post-COVID condition: a qualitative systematic review.European psychiatry : the journal of the Association of European Psychiatrists · 2024Pooled it
- Cognitive impairment, depression, and fatigue in post-COVID and post-vaccination syndrome: a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Cognition, Cytokines, Blood-Brain Barrier, and Beyond in COVID-19: A Narrative Review.International journal of molecular sciences · 2026Review
- Factors associated with severe neurological sequelae of COVID-19: findings from the multicenter COVID-BRAIN imaging cohort.Frontiers in human neuroscience · 2026Article
- Brain Volumetric Changes Post-COVID-19: A Systematic Review.Brain sciences · 2025Review
- Older People at Risk of Suicide: A Local Study During the COVID-19 Confinement Period.Healthcare (Basel, Switzerland) · 2025Article
- Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction.Nature medicine · 2025Article
- Executive deficits after SARS-CoV-2 infection: A cross-sectional population study.Brain, behavior, & immunity - health · 2024Article
- Investigating the Role of Serotonin Levels in Cognitive Impairments Associated with Long COVID-19.Chonnam medical journal · 2024Review
- Neurocognitive and Neuropsychiatric Sequelae in Long COVID-19 Infection.Brain sciences · 2024Article
- Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration.Molecular neurodegeneration · 2024Review
- A Comprehensive Review of COVID-19-Related Olfactory Deficiency: Unraveling Associations with Neurocognitive Disorders and Magnetic Resonance Imaging Findings.Diagnostics (Basel, Switzerland) · 2024Review
- Novel Advancements in COVID-19 and Neuroscience.Journal of personalized medicine · 2024Article
- Long COVID-19 and mnemonic effects: an integrative literature review.Revista da Associacao Medica Brasileira (1992) · 2024Review
- Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19.Brain communications · 2024Review
- Frequency and correlates of subjective cognitive complaints and objective cognitive screening results in African American adults following COVID-19 infection.Brain, behavior, & immunity - health · 2023Article
- Review
- The kynurenine pathway relates to post-acute COVID-19 objective cognitive impairment and PASC.Annals of clinical and translational neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aims to provide a critical overview of the literature on the relationships between post-acute COVID-19 infection and cognitive impairment, highlighting the limitations and confounding factors. A systematic search of articles published from 1 January 2020 to 1 July 2022 was performed in PubMed/Medline. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only studies using validated instruments for the assessment of cognitive impairment were included. Out of 5515 screened records, 72 studies met the inclusion criteria. The available evidence revealed the presence of impairment in executive functions, speed of processing, attention and memory in subjects recovered from COVID-19. However, several limitations of the literature reviewed should be highlighted: most studies were performed on small samples, not stratified by severity of disease and age, used as a cross-sectional or a short-term longitudinal design and provided a limited assessment of the different cognitive domains. Few studies investigated the neurobiological correlates of cognitive deficits in individuals recovered from COVID-19. Further studies with an adequate methodological design are needed for an in-depth characterization of cognitive impairment in individuals recovered from COVID-19.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.