ArticleJournal of personalized medicine2022
High Ultrafiltration Rate Is Associated with Increased All-Cause Mortality in Incident Hemodialysis Patients with a High Cardiothoracic Ratio.
Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Effect of reduced ultrafiltration rate on the cardiac biomarkers NT-proBNP and troponin T: a prospective crossover study.BMC nephrology · 2026Article
- Assessing hyperglucagonemia in maintenance hemodialysis: unaddressed methodological constraints and prognostic validity.International urology and nephrology · 2026Review
- Sex Differences in Associations Between Measures of Hemodialysis Adequacy and Quality, Cardiovascular Outcomes, and Mortality: A Systematic Review.Kidney medicine · 2026Article
- Prognostic value of ultrafiltration rate variability in maintenance hemodialysis patients: a prospective cohort study.Frontiers of medicine · 2025Article
- Utility of Central Venous Oxygen Saturation Gradient in Predicting Mortality in Dialysis with Catheter Access.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A high ultrafiltration rate (UFR) is associated with increased mortality in hemodialysis patients. However, whether a high UFR itself or heart failure with fluid overload followed by a high UFR causes mortality remains unknown. In this study, 2615 incident hemodialysis patients were categorized according to their initial cardiothoracic ratios (CTRs) to assess whether UFR was associated with mortality in patients with high or low CTRs. In total, 1317 patients (50.4%) were women and 1261 (48.2%) were diabetic. During 2246 (1087−3596) days of follow-up, 1247 (47.7%) cases of all-cause mortality were noted. UFR quintiles 4 and 5 were associated with higher risks of all-cause mortality than UFR quintile 2 in fully adjusted Cox regression analysis. As the UFR increased by 1 mL/kg/h, the risk of all-cause mortality increased 1.6%. Subgroup analysis revealed that in UFR quintile 5, hazard ratios (HRs) for all-cause mortality were 1.91, 1.48, 1.22, and 1.10 for CTRs of >55%, 50−55%, 45−50%, and <45%, respectively. HRs for all-cause mortality were higher in women and patients with high body weight. Thus, high UFRs may be associated with increased all-cause mortality in incident hemodialysis patients with a high CTR, but not in those with a low CTR.
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