Evidence map›Paper›PMID 36556275›Full record

ArticleJournal of personalized medicine2022

The Efficacy, Safety, and Satisfaction Associated with Switching from Brinzolamide or Brimonidine to Brinzolamide/Brimonidine in Open-Angle Glaucoma Patients.

Hiromitsu Onoe, Kazuyuki Hirooka, Mikio Nagayama, Hideki Mochizuki, Atsushi Hirota, Katsuyoshi Suzuki, Takeshi Sagara, Yoshiaki Kiuchi

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hiromitsu OnoeDepartment of Ophthalmology and Visual Science, Hiroshima University, Hiroshima 734-8551, Japan.ORCID 0000-0003-0494-0406
Kazuyuki HirookaDepartment of Ophthalmology and Visual Science, Hiroshima University, Hiroshima 734-8551, Japan.
Mikio NagayamaNagayama Eye Clinic, Okayama 714-0086, Japan.
Hideki MochizukiKusatsu Eye Clinic, Hiroshima 733-0861, Japan.
Atsushi HirotaHirota Eye Clinic, Yamaguchi 745-0017, Japan.
Katsuyoshi SuzukiSuzuki Eye Clinic, Yamaguchi 755-0155, Japan.
Takeshi SagaraSagara Eye Clinic, Yamaguchi 758-0021, Japan.
Yoshiaki KiuchiDepartment of Ophthalmology and Visual Science, Hiroshima University, Hiroshima 734-8551, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated switching from brinzolamide 1% or brimonidine 0.1% to a fixed-combination of brinzolamide 1% and brimonidine 0.1%, and then determined the efficacy, safety, and satisfaction associated with these changes in glaucoma patients. This prospective, nonrandomized study evaluated a total of 31 enrolled glaucoma patients who underwent treatment with at least brinzolamide 1% or brimonidine 0.1%. Patients were administered a brinzolamide/brimonidine fixed-combination ophthalmic suspension (BBFC) after being switched from their original brinzolamide 1% or brimonidine 0.1% therapy. All other intraocular pressure (IOP)-lowering medications currently being used were continued. IOP, superficial punctate keratopathy (SPK), and conjunctival hyperemia data obtained at baseline and then at 4 and 12 weeks were evaluated. To assess the changes in treatment satisfaction, this study utilized the Treatment Satisfaction Questionnaire for Medication-9 (TSQM-9). There was a significant decrease in the mean baseline IOP from 15.7 ± 4.9 mmHg to 13.6 ± 4.4 (

Indexed as

brimonidinebrinzolamideglaucomasatisfaction

Identifiers

PMID36556275
PMCPMC9782658

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.