Evidence map›Paper›PMID 36556247›Full record

ArticleJournal of personalized medicine2022

Diversity of Circulating NKT Cells in Defense against Carbapenem-Resistant Klebsiella Pneumoniae Infection.

Yidi Wang, Feng Zang, Xiangyu Ye, Zhanjie Li, Wenhao Zhu, Xiaoxiao Cao, Xuehong Cai, Xinyan Ma, Lei Xu, Yongxiang Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yidi WangDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210000, China.
Feng ZangDepartment of Infection Control, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210000, China.
Xiangyu YeDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210000, China.
Zhanjie LiDepartment of Infection Control, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210000, China.
Wenhao ZhuDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210000, China.
Xiaoxiao CaoDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210000, China.
Xuehong CaiDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210000, China.
Xinyan MaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210000, China.
Lei XuDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210000, China.
Yongxiang ZhangDepartment of Infection Control, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210000, China.
Liqing BiDepartment of Neurosurgery ICU, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210000, China.
Rongbin YuDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210000, China.
Peng HuangDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210000, China.

Funding

National Natural Science Foundation of China 82173585Natural Science Foundation of Jiangsu Higher Education Institutions of China 21KJB330005Priority Academic Program Development of Jiangsu Higher Education Institutions NA
6 · The paper itself

Abstract

Nosocomial infection caused by carbapenem-resistant Klebsiella pneumonia (CRKP) infection has become a global public health problem. Human NK and NKT cells in peripheral immune responses are recognized as occupying a critical role in anti-bacterial immunity. Through performed scRNA-seq on serial peripheral blood samples from 3 patients with CRKP undergoing colonization, infection, and recovery conditions, we were able to described the immune responses of NK and NKT cells during CRKP infection and identified a mechanism that could contribute to CRKP clearance. The central player of CRKP infection process appears to be the NKT subset and CD56hiNKT subset which maintained immune competence during CRKP colonization. With time, CRKP leads to the loss of NK and CD160hiNKT cells in peripheral blood, resulting in suppressed immune responses and increased susceptibility to opportunistic infection. In summary, our study identified a possible mechanism for the CRKP invasion and to decipher the clues behind the host immune response that influences CRKP infection pathogenesis.

Indexed as

carbapenem-resistant Klebsiella pneumoniaehost immunitynatural killer T cellsscRNA-seq

Identifiers

PMID36556247
PMCPMC9783671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.