Evidence map›Paper›PMID 36556244›Full record

ArticleJournal of personalized medicine2022

Effect of a NICU to Home Physical Therapy Intervention on White Matter Trajectories, Motor Skills, and Problem-Solving Skills of Infants Born Very Preterm: A Case Series.

Christiana Dodd Butera, Claire Rhee, Claire E Kelly, Thijs Dhollander, Deanne K Thompson, Jessica Wisnowski, Rebecca M Molinini, Barbara Sargent, Natasha Lepore, Greg Vorona and 8 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Christiana Dodd ButeraDivision of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA.
Claire RheeDivision of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-6136-409X
Claire E KellyVictorian Infant Brain Studies and Developmental Imaging, Murdoch Children's Research Institute, Parkville, VIC 3052, Australia.
Thijs DhollanderDevelopmental Imaging, Murdoch Children's Research Institute, Parkville, VIC 3052, Australia.
Deanne K ThompsonVictorian Infant Brain Studies and Developmental Imaging, Murdoch Children's Research Institute, Parkville, VIC 3052, Australia.ORCID 0000-0001-8017-5756
Jessica WisnowskiDepartments of Radiology and Pediatrics (Neonatology), Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Rebecca M MolininiDepartment of Physical Therapy, Virginia Commonwealth University, Richmond, VA 23284, USA.
Barbara SargentDivision of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-2261-6610
Natasha LeporeCIBORG Laboratory, Department of Radiology, University of Southern California, Los Angeles, CA 90089, USA.
Greg VoronaDepartment of Radiology, Virginia Commonwealth University, Richmond, VA 23284, USA.
Dave BessomDepartment of Radiology, Children's Hospital of Richmond at VCU, Richmond, VA 23284, USA.
Mary S ShallDepartment of Physical Therapy, Virginia Commonwealth University, Richmond, VA 23284, USA.
Jennifer BurnsedDivision of Neonatology, Departments of Pediatrics and Neurology, University of Virginia, Charlottesville, VA 22903, USA.
Richard D StevensonDivision of Neurodevelopmental and Behavioral Pediatrics, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Shaaron BrownDepartment of Physical Therapy, Virginia Commonwealth University, Richmond, VA 23284, USA.
Amy HarperDepartment of Neurology, Virginia Commonwealth University, Richmond, VA 23284, USA.
Karen D Hendricks-MuñozDepartment of Pediatrics, Virginia Commonwealth University School of Medicine, Children's Hospital of Richmond at VCU, Richmond, VA 23284, USA.ORCID 0000-0002-6367-0373
Stacey C DusingDivision of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0003-3847-3893

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
6 · The paper itself

Abstract

Infants born very preterm (VPT; ≤29 weeks of gestation) are at high risk of developmental disabilities and abnormalities in neural white matter characteristics. Early physical therapy interventions such as Supporting Play Exploration and Early Development Intervention (SPEEDI2) are associated with improvements in developmental outcomes. Six VPT infants were enrolled in a randomised clinical trial of SPEEDI2 during the transition from the neonatal intensive care unit to home over four time points. Magnetic resonance imaging scans and fixel-based analysis were performed, and fibre density (FD), fibre cross-section (FC), and fibre density and cross-section values (FDC) were computed. Changes in white matter microstructure and macrostructure were positively correlated with cognitive, motor, and motor-based problem solving over time on developmental assessments. In all infants, the greatest increase in FD, FC, and FDC occurred between Visit 1 and 2 (mean chronological age: 2.68-6.22 months), suggesting that this is a potential window of time to optimally support adaptive development. Results warrant further studies with larger groups to formally compare the impact of intervention and disparity on neurodevelopmental outcomes in infants born VPT.

Indexed as

corticospinal tractearly interventionfixel-based analysispreterm infants

Identifiers

PMID36556244
PMCPMC9784100

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.