Evidence map›Paper›PMID 36556152›Full record

ReviewJournal of clinical medicine2022

Axial Spondyloarthritis: Reshape the Future-From the "2022 GISEA International Symposium".

Fausto Salaffi, Cesare Siragusano, Alessandra Alciati, Giulia Cassone, Salvatore D'Angelo, Serena Guiducci, Ennio Giulio Favalli, Fabrizio Conti, Elisa Gremese, Florenzo Iannone and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Fausto SalaffiRheumatology Clinic, Ospedale Carlo Urbani, Università Politecnica delle Marche, 60035 Jesi, Italy.
Cesare SiragusanoRheumatology Unit, Department of Experimental and Internal Medicine, University of Messina, 98125 Messina, Italy.
Alessandra AlciatiDepartment of Clinical Neurosciences, Hermanas Hospitalarias, Villa San Benedetto Menni Hospital, Como, and Humanitas Clinical and Research Centre, Rozzano, 20089 Milan, Italy.ORCID 0000-0002-8971-4696
Giulia CassoneRheumatology Unit, Azienda Ospedaliera Policlinico di Modena, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-3454-401X
Salvatore D'AngeloRheumatology Institute of Lucania and Rheumatology Department of Lucania, San Carlo Hospital of Potenza, 85100 Potenza, Italy.
Serena GuiducciDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Ennio Giulio FavalliDivision of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, 20122 Milan, Italy.
Fabrizio ContiLupus Clinic, Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Sapienza University of Rome, 00161 Rome, Italy.
Elisa GremeseRheumatology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Florenzo IannoneRheumatology Unit, Department of Emergency Surgery and Organ Transplantations, University of Bari, 70121 Bari, Italy.ORCID 0000-0003-0474-5344
Roberto CaporaliDivision of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, 20122 Milan, Italy.
Marco SebastianiRheumatology Unit, Azienda Ospedaliera Policlinico di Modena, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-1294-6421
Gian Franco FerraccioliSchool of Medicine, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Giovanni LapadulaRheumatology Unit, Department of Emergency Surgery and Organ Transplantations, University of Bari, 70121 Bari, Italy.ORCID 0000-0002-8427-6092
Fabiola AtzeniRheumatology Unit, Department of Experimental and Internal Medicine, University of Messina, 98125 Messina, Italy.
University of Bari Aldo Moro · ITUniversity of Messina · ITUniversity of Milan · ITUniversity of Modena and Reggio Emilia · ITAgostino Gemelli University Polyclinic · ITIRCCS Humanitas Research Hospital · ITMarche Polytechnic University · ITOspedale San Carlo · ITSapienza University of Rome · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term "axial spondyloarthritis" (axSpA) refers to a group of chronic rheumatic diseases that predominantly involve the axial skeleton and consist of ankylosing spondylitis, reactive arthritis, arthritis/spondylitis associated with psoriasis (PsA) and arthritis/spondylitis associated with inflammatory bowel diseases (IBD). Moreover, pain is an important and common symptom of axSpA. It may progress to chronic pain, a more complicated bio-psychosocial phenomena, leading to a significant worsening of quality of life. The development of the axSpA inflammatory process is grounded in the complex interaction between genetic (such as HLA B27), epigenetic, and environmental factors associated with a dysregulated immune response. Considering the pivotal contribution of IL-23 and IL-17 in axSpA inflammation, the inhibition of these cytokines has been evaluated as a potential therapeutic strategy. With this context, here we discuss the main pathogenetic mechanisms, therapeutic approaches and the role of pain in axSpA from the 2022 International GISEA/OEG Symposium.

Indexed as

axial spondyloarthritispainpathogenesistherapy

Identifiers

PMID36556152
PMCPMC9780899
OpenAlexW4312194526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.