ArticleJournal of clinical medicine2022
Syphilis Infections, Reinfections and Serological Response in a Large Italian Sexually Transmitted Disease Centre: A Monocentric Retrospective Study.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Outcomes following traumatic brain injury in patients with Pre-Injury antiplatelets versus anticoagulants: A systematic review and Meta-Analysis.Neurosurgical review · 2025Pooled it
- Risk factors of serofast state in patients undergoing syphilis: a meta-analysis of 17 cohort studies.Frontiers in immunology · 2025Pooled it
- Comparable treatment response rates with benzathine penicillin and doxycycline in early syphilis: evidence from a large German cohort.Infection · 2026Article
- Clinical Characteristics and Risk Factors for Syphilis Among People Living With Human Immunodeficiency Virus: A Nationwide Population-Based Cohort Study in Korea.Journal of Korean medical science · 2026Article
- Evaluating syphilis transmission among MSM population: a mathematical model for reinfection, two-stage treatment, and treatment failure.Frontiers in public health · 2026Article
- Dynamics and Persistence of a Generalized Multi-strain SIS Model.Bulletin of mathematical biology · 2025Article
- The Resurgence of Syphilis: A 20-Year Evaluation of Epidemiological Trends and Serological Test Performance Using Rapid Plasma Reagin and Indirect Hemagglutination Assays.Medicina (Kaunas, Lithuania) · 2025Article
- Coinfection of syphilis and HIV: epidemiological evaluation at the Dermatology Department in Lodz, Poland.Postepy dermatologii i alergologii · 2025Article
- Serofast state after syphilis treatment: implications and recommendations for clinical practice. Narrative review.Postepy dermatologii i alergologii · 2025Review
- Analysis of Factors Determining Serologic Response to Treatment of Early Syphilis in Adult Men.Infectious disease reports · 2025Article
- Predicting the Risk of HIV Infection and Sexually Transmitted Diseases Among Men Who Have Sex With Men: Cross-Sectional Study Using Multiple Machine Learning Approaches.Journal of medical Internet research · 2025Article
- The Role of Traditional and Reverse Algorithms in the Diagnosis of Syphilis in HIV-Infected Individuals: A Case Study on Istanbul.Diagnostics (Basel, Switzerland) · 2025Article
- The Rise of Syphilis Infections and Reinfections over a Decade (2009-2019) in the Bolognese Area: A Retrospective Analysis.Microorganisms · 2025Article
- Atypical Dermatological Manifestations of Syphilis in Advanced HIV: A Case-Based Narrative Review.Mediterranean journal of hematology and infectious diseases · 2025Article
- The Resurgence ofInternational journal of environmental research and public health · 2024Article
- Sexually Transmitted Infections in People with Human Immunodeficiency Virus.Infectious disease clinics of North America · 2024Review
- Acquired syphilis in older people in Brazil from 2010-2020.PloS one · 2024Article
- Review
- Exposure toMicroorganisms · 2023Article
- Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Syphilis infection does not confer definitive and protective immunity against reinfection, and crucial aspects of repeated episodes of syphilis are far from being understood, especially among people living with HIV (PLWH). Methods: In order to explore the burden of syphilis in a large cohort of HIV-negative patients and PLWH, this retrospective study describes the demographics, clinical presentation and treatment outcome of patients with syphilis treated at our clinic from 2013 to 2021. Results: Within the study period, 1859 syphilis episodes (827, 44.5% first infections and 1032, 55.5% reinfections) were recorded. A total of 663 patients, of whom 347 (52%) had PLWH, were considered. Syphilis was mostly diagnosed in males (77%) and European (79%) patients. More than half of syphilis episodes were recorded during the late latent stage (64%) or during follow-up/screening visits for other diseases, while symptomatic stages led to a diagnosis in almost half of HIV-negative patients (p < 0.001). PLWH with syphilis infection were predominantly homo/bisexual (p < 0.001). A significantly higher rate of syphilis reinfection was observed in PLWH, who also demonstrated a higher range of subsequent episodes. The serofast state was found to be similar at the 6- and 12-month follow-up visits. The multivariate analysis carried out in the HIV-positive group showed that an RPR titre >1:16 was an independent predictor for serological non-response. Conclusions: Syphilis reinfections are predominantly diagnosed in HIV-positive MSM. The high rate of asymptomatic presentation among PLWH supports the role of periodical syphilis screening. In PLWH, the only baseline factor associated with an increased risk of non-response was an RPR titre >1:16, while assessment at 12 months after treatment increased the possibility of detecting a serological response, indicating that PLWH have a slower serological response to treatment.
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