Evidence map›Paper›PMID 36556021›Full record

ReviewJournal of clinical medicine2022

Central versus Peripheral Postcardiotomy Veno-Arterial Extracorporeal Membrane Oxygenation: Systematic Review and Individual Patient Data Meta-Analysis.

Fausto Biancari, Alexander Kaserer, Andrea Perrotti, Vito G Ruggieri, Sung-Min Cho, Jin Kook Kang, Magnus Dalén, Henryk Welp, Kristján Jónsson, Sigurdur Ragnarsson and 23 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Current insights on temporary mechanical circulatory support in adults with post-cardiotomy cardiogenic shock.European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 13 countries.

Fausto BiancariHeart and Lung Center, Helsinki University Hospital, Haartmaninkatu 4, P.O. Box 340, 00029 Helsinki, Finland.ORCID 0000-0001-5028-8186
Alexander KasererInstitute of Anesthesiology, University and University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0001-9105-8328
Andrea PerrottiDepartment of Thoracic and Cardio-Vascular Surgery, University Hospital Jean Minjoz, 25030 Besançon, France.ORCID 0000-0002-8582-242X
Vito G RuggieriDivision of Cardiothoracic and Vascular Surgery, Robert Debré University Hospital, 51100 Reims, France.
Sung-Min ChoDivisions of Neurosciences, Critical Care and Cardiac Surgery, Departments of Neurology, Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-5132-0958
Jin Kook KangDivisions of Neurosciences, Critical Care and Cardiac Surgery, Departments of Neurology, Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21201, USA.
Magnus DalénDepartment of Molecular Medicine and Surgery, Department of Cardiac Surgery, Karolinska Institutet, Karolinska University Hospital, 17176 Stockholm, Sweden.ORCID 0000-0001-5352-5132
Henryk WelpDepartment of Cardiothoracic Surgery, Münster University Hospital, 48149 Münster, Germany.ORCID 0000-0002-4216-6223
Kristján JónssonDepartment of Cardiac Surgery, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.ORCID 0000-0002-6689-6976
Sigurdur RagnarssonDepartment of Cardiothoracic Surgery, University of Lund, 10392 Lund, Sweden.
Francisco J Hernández PérezPuerta de Hierro University Hospital, 29222 Madrid, Spain.
Giuseppe GattiDivision of Cardiac Surgery, Cardio-Thoracic and Vascular Department, University Hospital of Trieste, 34128 Trieste, Italy.ORCID 0000-0002-9996-6133
Khalid AlkhameesPrince Sultan Cardiac Center, Al Hassa 36441, Saudi Arabia.
Antonio LoforteDepartment of Cardiothoracic, Transplantation and Vascular Surgery, S. Orsola Hospital, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-3689-0477
Andrea LechiancoleCardiothoracic Department, University Hospital of Udine, 33100 Udine, Italy.
Stefano RosatoCenter for Global Health, Italian National Institute, 00161 Rome, Italy.ORCID 0000-0002-6690-5537
Cristiano SpadaccioDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, MN 13400, USA.
Matteo PettinariDepartment of Cardiovascular Surgery, Ziekenhuis Oost-Limburg, 3600 Genk, Belgium.ORCID 0000-0002-2611-9566
Antonio FioreDepartment of Cardiac Surgery, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 94000 Creteil, France.ORCID 0000-0001-7962-7276
Timo MäkikallioDepartment of Medicine, South-Karelia Central Hospital, University of Helsinki, 53130 Lappeenranta, Finland.
Sebastian D SahliInstitute of Anesthesiology, University and University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-2030-0313
Camilla L'AcquaAnesthesia and Intensive Care Unit, Centro Cardiologico Monzino, 20138 Milan, Italy.ORCID 0000-0002-0533-8284
Amr A ArafatAdult Cardiac Surgery, Prince Sultan Cardiac Center, Riyadh 12611, Saudi Arabia.
Monirah A AlbabtainCardiology Clinical Pharmacy, Prince Sultan Cardiac Center, Riyadh 12611, Saudi Arabia.
Mohammed M AlBarakIntensive Care Department, Prince Sultan Cardiac Center, Riyadh 12611, Saudi Arabia.
Mohamed LaimoudCardiac Surgical Intensive Care Department, King Faisal Specialist Hospital and Research Center, Riyadh 11564, Saudi Arabia.ORCID 0000-0002-5069-2813
Ilija DjordjevicDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, Germany.ORCID 0000-0002-5810-8626
Ihor KrasivskyiDepartment of Cardiothoracic Surgery, University Hospital Cologne, 50937 Cologne, Germany.ORCID 0000-0003-0573-8218
Robertas Samalavicius2nd Department of Anesthesia, Vilnius University Hospital Santaros Klinikos, 08410 Vilnius, Lithuania.
Lina Puodziukaite2nd Department of Anesthesia, Vilnius University Hospital Santaros Klinikos, 08410 Vilnius, Lithuania.
Marta Alonso-Fernandez-GattaCardiology Department, University Hospital of Salamanca, Instituto de Investigación Biomédica de Salamanca, 37007 Salamanca, Spain.ORCID 0000-0002-4363-8835
Markus J WilhelmClinic for Cardiac Surgery, University Heart Center, University and University Hospital Zurich, 8091 Zurich, Switzerland.
Giovanni MariscalcoDepartment of Intensive Care Medicine and Cardiac Surgery, Glenfield Hospital, University Hospitals of Leicester, Leicester LE2 9QP, UK.
Prince Sultan University · SAUniversity Hospital of Zurich · CHJohns Hopkins University · USUniversity Hospital Cologne · DEUniversity of Helsinki · FIVilnius University · LTAssistance Publique – Hôpitaux de Paris · FRCairo University · EGCentre Hospitalier Universitaire de Besançon · FRCentre Hospitalier Universitaire de Reims · FRCentro Cardiologico Monzino · ITGlenfield Hospital · GBHospital Universitario Puerta de Hierro Majadahonda · ESInstituto de Salud Carlos III · ESKarolinska University Hospital · SELund University · SEMayo Clinic in Arizona · USSahlgrenska University Hospital · SEUniversity Hospital Münster · DEUniversity of Bologna · IT

Funding

CLots and Oxygen in Va-ExtracorpoReal membrane oxygenation (CLOVER) studyK23HL157610 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Sung-Min Cho · 2022 to 2026
$797k
NHLBI NIH HHS K23 HL157610NHLBI NIH HHS L30 HL165486
6 · The paper itself

Abstract

backgroundIt is unclear whether peripheral arterial cannulation is superior to central arterial cannulation for postcardiotomy veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

methodsA systematic review was conducted using PubMed, Scopus, and Google Scholar to identify studies on postcardiotomy VA-ECMO for the present individual patient data (IPD) meta-analysis. Analysis was performed according to the intention-to-treat principle.

resultsThe investigators of 10 studies agreed to participate in the present IPD meta-analysis. Overall, 1269 patients were included in the analysis. Crude rates of in-hospital mortality after central versus peripheral arterial cannulation for VA-ECMO were 70.7% vs. 63.7%, respectively (adjusted OR 1.38, 95% CI 1.08-1.75). Propensity score matching yielded 538 pairs of patients with balanced baseline characteristics and operative variables. Among these matched cohorts, central arterial cannulation VA-ECMO was associated with significantly higher in-hospital mortality compared to peripheral arterial cannulation VA-ECMO (64.5% vs. 70.8%,

conclusionsAmong patients requiring postcardiotomy VA-ECMO, central arterial cannulation was associated with an increased risk of in-hospital mortality compared to peripheral arterial cannulation. This increased risk is of limited magnitude, and further studies are needed to confirm the present findings and to identify the mechanisms underlying the potential beneficial effects of peripheral VA-ECMO.

Indexed as

cardiac surgerycentralECMOextracorporeal membrane oxygenationperipheralpostcardiotomy

Identifiers

PMID36556021
PMCPMC9785985
OpenAlexW4311393069

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.