Evidence map›Paper›PMID 36556000›Full record

ArticleJournal of clinical medicine2022

Real-Life Effectiveness of Subcutaneous Immune Therapy with Carbamylated Monomeric Allergoids on Mite, Grass, and Pellitory Respiratory Allergy: A Retrospective Study.

Mario Di Gioacchino, Loredana Della Valle, Rocco Mangifesta, Arianna Lumaca, Francesco Cipollone, Franco Frati, Enrico Compalati, Eralda Lekli, Etleva Qirco Loloci, Francesca Santilli

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Mario Di GioacchinoYDA-Institute for Immunotherapy and Advanced Biological Treatments, 65100 Pescara, Italy.ORCID 0000-0002-9224-5886
Loredana Della VallePneumology Division, University Hospital, 66100 Chieti, Italy.
Rocco MangifestaCentre of Advanced Studies and Technology (CAST), G. d'Annunzio University, 66100 Chieti, Italy.
Arianna LumacaSpecialization School in Allergology and Clinical Immunology, G. d'Annunzio University, 66100 Chieti, Italy.
Francesco CipolloneCentre of Advanced Studies and Technology (CAST), G. d'Annunzio University, 66100 Chieti, Italy.
Franco FratiMedical Department, Lofarma, 20143 Milan, Italy.
Enrico CompalatiMedical Department, Lofarma, 20143 Milan, Italy.
Eralda LekliAllergology, Salus Hospital, 1031 Tirana, Albania.
Etleva Qirco LolociAllergology and Clinical Immunology Service, Mother Teresa UHC, 1031 Tirana, Albania.
Francesca SantilliCentre of Advanced Studies and Technology (CAST), G. d'Annunzio University, 66100 Chieti, Italy.ORCID 0000-0002-4593-905X
University of Chieti-Pescara · ITLofarma (Italy) · ITMother Teresa Hospital · AL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: real-life studies are encouraged to evaluate the effectiveness and safety of allergen immunotherapy (AIT). In this context, a retrospective cohort study was conducted to assess the effectiveness and safety of carbamylated monomeric allergoid subcutaneous immunotherapy (MA-SCIT), along with patient satisfaction. Methods: a total of 291 patients with rhinoconjunctivitis with or without asthma with inhalant (house dust mite, grass, and pellitory) allergies were enrolled in this study. Perceived efficacy and perceived satisfaction with MA-SCIT, symptom score by VAS, ARIA classification of rhinitis, drug consumption, number of asthma worsening episodes, and asthma symptom control were evaluated by questionnaires before, after one year, at the end of treatment, and after one or two years of MA-SCIT. Results: the overall symptom score significantly decreased over the years of MA-SCIT, irrespective of specific sensitization (p < 0.01). There was a substantial amelioration of rhinitis severity, with a significant reduction (p < 0.01) in drug use. A significant reduction was observed in the asthma symptom VAS score and asthma-worsening episodes requiring systemic steroids. None of the patients reported any severe adverse reactions. Finally, 90% of the patients reported full satisfaction with the treatment. Conclusions: the study showed that AIT with carbamylated monomeric allergoids of grass, pellitory, and mites was effective and well tolerated by patients.

Indexed as

carbamylated monomeric allergoidpatient satisfactionreal-life studyrespiratory allergySCIT

Identifiers

PMID36556000
PMCPMC9781390
OpenAlexW4312141330

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.