ArticleJournal of clinical medicine2022
Hypothermic Oxygenated Machine Perfusion (HOPE) Prior to Liver Transplantation Mitigates Post-Reperfusion Syndrome and Perioperative Electrolyte Shifts.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Factors associated with major complications defined by Clavien-Dindo classification 3-5 after liver transplantation: a prospective multicenter cohort study.Frontiers in surgery · 2025Trial
- Immune cells in liver transplantation: Dual roles, mechanistic insights, and targeted therapeutic strategies.Immunologic research · 2026Review
- The Impact of Normothermic Machine Liver Perfusion on Early Renal Outcomes After Simultaneous Liver-kidney Transplantation: A Propensity Score-Matched Analysis.Transplantation direct · 2026Article
- Fluorescence spectroscopy precorrection model robust to large variability of optical properties: application to point of care quantitative liver graft viability assessment.Biomedical optics express · 2026Article
- Propensity Score-matched Real-world Data: HCC Recurrence Rates After DBD Liver Transplantation in Times of Machine Perfusion.Transplantation direct · 2026Article
- An Iterative Design Approach to Development of an Ex Situ Normothermic Multivisceral Perfusion Platform.Journal of clinical medicine · 2025Article
- Post-reperfusion syndrome in liver transplant recipients: What is new in prevention and management?World journal of critical care medicine · 2025Review
- Anesthesia management for total robotic liver transplantation: Inaugural case series in Europe.Annals of hepato-biliary-pancreatic surgery · 2025Article
- Perspectives and Tools in Liver Graft Assessment: A Transformative Era in Liver Transplantation.Biomedicines · 2025Review
- Mono-HOPE Versus Dual-HOPE in Liver Transplantation: A Propensity Score-Matched Evaluation of Early Graft Outcome.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- A Review of the Risk Factors and Approaches to Prevention of Post-Reperfusion Syndrome During Liver Transplantation.Organogenesis · 2024Review
- Impact of Hypothermic Oxygenated Machine Perfusion on Immune Cell Clearance in Liver Transplantation: Enhancing Graft Function and Post-Transplant Outcomes.Journal of clinical medicine · 2024Article
- Impact of Paired Remote Ischemic Preconditioning on Postreperfusion Syndrome in Living-Donor Liver Transplantation: A Propensity-Score Matching Analysis.Medicina (Kaunas, Lithuania) · 2024Observational
- [Machine perfusion in transplantation surgery].Chirurgie (Heidelberg, Germany) · 2024Review
- HOPE Mitigates Ischemia-Reperfusion Injury in Ex-Situ Split Grafts: A Comparative Study With Living Donation in Pediatric Liver Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Establishing a HOPE Program in a Real-life Setting: A Brazilian Case Series.Transplantation direct · 2023Article
- Benefits of Hypothermic Oxygenated Perfusion Versus Static Cold Storage in Liver Transplant: A Comprehensive Systematic Review and Meta-analysis.Journal of clinical and experimental hepatologyArticle
- Intraoperative transesophageal echocardiography in liver transplantation: A systematic review of clinical utility in managing hemodynamic challenges and complications.Tzu chi medical journalReview
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Background: Post-reperfusion syndrome (PRS) and electrolyte shifts (ES) represent considerable challenges during liver transplantation (LT) being associated with significant morbidity. We aimed to investigate the impact of hypothermic oxygenated machine perfusion (HOPE) on PRS and ES in LT. (2) Methods: In this retrospective study, we compared intraoperative parameters of 100 LTs, with 50 HOPE preconditioned liver grafts and 50 grafts stored in static cold storage (SCS). During reperfusion phase, prospectively registered serum parameters and vasopressor administration were analyzed. (3) Results: Twelve percent of patients developed PRS in the HOPE cohort vs. 42% in the SCS group (p = 0.0013). Total vasopressor demand in the first hour after reperfusion was lower after HOPE pretreatment, with reduced usage of norepinephrine (−26%; p = 0.122) and significant reduction of epinephrine consumption (−52%; p = 0.018). Serum potassium concentration dropped by a mean of 14.1% in transplantations after HOPE, compared to a slight decrease of 1% (p < 0.001) after SCS. The overall incidence of early allograft dysfunction (EAD) was reduced by 44% in the HOPE group (p = 0.04). (4) Conclusions: Pre-transplant graft preconditioning with HOPE results in higher hemodynamic stability during reperfusion and lower incidence of PRS and EAD. HOPE has the potential to mitigate ES by preventing hyperpotassemic complications that need to be addressed in LT with HOPE-pre-treated grafts.
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Registered trials
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