Evidence map›Paper›PMID 36555939›Full record

ArticleJournal of clinical medicine2022

Long-Term Domiciliary High-Flow Nasal Therapy in Patients with Bronchiectasis: A Preliminary Retrospective Observational Case-Control Study.

Claudia Crimi, Santi Nolasco, Raffaele Campisi, Mattia Nigro, Pietro Impellizzeri, Andrea Cortegiani, Alberto Noto, Andrea Gramegna, Carlo Vancheri, Francesco Blasi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  7. Patient-managed interventions for adults with bronchiectasis: evidence, challenges and prospects.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
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  11. Article
  12. Article
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  14. New Frontiers in High-Flow Therapy.Open respiratory archives
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Claudia CrimiDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-9088-5214
Santi NolascoDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-3995-7662
Raffaele CampisiRespiratory Medicine Unit, Policlinico "G. Rodolico-San Marco" University Hospital, 95123 Catania, Italy.ORCID 0000-0001-9305-6748
Mattia NigroDepartment of Biomedical Sciences, Humanitas University, 20072 Milan, Italy.ORCID 0000-0003-4735-823X
Pietro ImpellizzeriDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-1299-4498
Andrea CortegianiDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0003-1416-9993
Alberto NotoDepartment of Human Pathology of the Adult and Evolutive Age "Gaetano Barresi", Division of Anesthesia and Intensive Care, University of Messina, Policlinico "G. Martino", 98125 Messina, Italy.
Andrea GramegnaDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milano, Italy.
Carlo VancheriDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Francesco BlasiDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milano, Italy.ORCID 0000-0002-2285-9970
Nunzio CrimiRespiratory Medicine Unit, Policlinico "G. Rodolico-San Marco" University Hospital, 95123 Catania, Italy.
Stefano AlibertiDepartment of Biomedical Sciences, Humanitas University, 20072 Milan, Italy.
Annalisa CarlucciDepartment of Medicine and Surgery, Università degli Studi dell'Insubria, 21100 Varese, Italy.
University of Catania · ITHumanitas University · ITUniversity of Milan · ITAzienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · ITUniversity of Insubria · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-flow nasal therapy (HFNT) provides several pathophysiological benefits in chronic respiratory disorders. We aimed to evaluate the effectiveness of long-term HFNT in patients with bronchiectasis (BE).

methodsThis is a retrospective bicentric case-control study of outpatients with BE on optimized medical treatment with a severe exacerbation requiring hospitalization in the previous year. Patients on long-term home HFNT (cases) and patients on optimized medical treatment alone (controls) were matched by age, sex, bronchiectasis severity index, and exacerbations in the previous year. Data on BE exacerbations, hospitalizations/year, mucus features, respiratory symptoms, and pulmonary function were collected. The primary outcome was the change from baseline in the exacerbation rates at 12 months between groups.

results20 patients in the HFNT group and 20 controls were included. A significant reduction in exacerbations [-1.9 (-2.8 to -0.9),

conclusionsIn this preliminary study, long-term domiciliary HFNT improved the clinical course of patients with BE.

Indexed as

bronchiectasisexacerbationhigh-flow nasal cannulahigh-flow nasal therapyhospitalizationmucus

Identifiers

PMID36555939
PMCPMC9782624
OpenAlexW4311995393

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.