Evidence map›Paper›PMID 36555889›Full record

ArticleJournal of clinical medicine2022

Management and Predictors of Treatment Failure in Patients with Chemo-Resistant/Relapsed Gestational Trophoblastic Neoplasia with Lung Metastasis.

Yujia Kong, Weidi Wang, Jinkai Lin, Xirun Wan, Fengzhi Feng, Tong Ren, Jun Zhao, Junjun Yang, Yang Xiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Pulmonary resection of residual lesions of pulmonary metastasis from gestational trophoblastic neoplasia.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yujia KongDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Obstetrics and Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China.
Weidi WangDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Obstetrics and Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China.
Jinkai LinDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Obstetrics and Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China.
Xirun WanDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Obstetrics and Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China.
Fengzhi FengDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Obstetrics and Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China.
Tong RenDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Obstetrics and Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China.
Jun ZhaoDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Obstetrics and Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China.
Junjun YangDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Obstetrics and Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China.ORCID 0000-0002-5625-0119
Yang XiangDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Obstetrics and Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

National High Level Hospital Clinical Research Funding 2022-PUMCH-B-084National Natural Science Foundation of China 81971475National Natural Science Foundation of China 81972451
6 · The paper itself

Abstract

The aim of the study was to assess the effectiveness of a combined treatment modality of salvage chemotherapy and pulmonary resection in chemo-resistant/relapsed gestational trophoblastic neoplasia (GTN) with lung metastasis and identify predictors of treatment failure. Data of patients with chemo-resistant/relapsed GTN with lung metastasis who received salvage chemotherapy combined with pulmonary resection were retrospectively analyzed. Among 134 included patients, the number of preoperative chemotherapy regimens ranged from 2−8 (median, 3), and courses ranged from 4−37 (median, 14). Pulmonary lobectomies, segmentectomies, wedge resections, and lobectomies plus wedge resections were performed in 84, 5, 35, and 10 patients, respectively. After completion of treatment, 130 (97.0%) patients achieved complete remission. In the entire cohort, the 5-year overall survival (OS) rate was 87.6%. OS rates were similar between stage III and stage IV disease cohorts (89.4% vs. 75.0%, p = 0.137). Preoperative β-human chorionic gonadotropin (β-hCG) levels > 10 IU/L (p = 0.027) and number of preoperative chemotherapy regimens > 3 (p = 0.018) were predictors of treatment failure. The combined treatment modality of salvage chemotherapy and pulmonary resection is effective in patients with chemo-resistant/relapsed GTN with lung metastasis, improving their prognoses. Patients with preoperative serum β-hCG >10 IU/L and those with >3 chemotherapy regimens preoperatively may not benefit from this multidisciplinary treatment.

Indexed as

chemo-resistancegestational trophoblastic neoplasialung metastasispulmonary resectionrelapsesalvage chemotherapy

Identifiers

PMID36555889
PMCPMC9784534
OpenAlexW4311859176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.