Evidence map›Paper›PMID 36555790›Full record

ArticleInternational journal of molecular sciences2022

Neuroprotection of Kaji-Ichigoside F1 via the BDNF/Akt/mTOR Signaling Pathways against NMDA-Induced Neurotoxicity.

Faju Chen, Li Wang, Fengli Jin, Liangqun Li, Tao Wang, Ming Gao, Lilang Li, Yu Wang, Zhongsheng Lou, Juan Yang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Neuroprotective Effects ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. TheFoods (Basel, Switzerland) · 2026
    Article
  3. Cili (Current issues in molecular biology · 2026
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Faju ChenSchool of Basic Medicine, Guizhou Medical University, Guiyang 550025, China.
Li WangState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Fengli JinEngineering Research Center of Natural Product Efficient Utilization in Guizhou, The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
Liangqun LiState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Tao WangEngineering Research Center of Natural Product Efficient Utilization in Guizhou, The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China.
Ming GaoState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Lilang LiState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Yu WangState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Zhongsheng LouState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Juan YangState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Qiji LiState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.ORCID 0000-0003-0710-4569
Xiaosheng YangSchool of Basic Medicine, Guizhou Medical University, Guiyang 550025, China.
Guiyang Medical University · CNKey Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences · CN

Funding

Characteristic Key Laboratory for the higher education institutions in Guizhou 2020-018Guizhou Province Innovation Capability Improvement Platform 2020-4013Guizhou Provincial Science and Technology Foundation 2023-263the National Natural Science Foundation of China 32160104the National Natural Science Foundation of China 82160807the National Natural Science Foundation of China U1812403
6 · The paper itself

Abstract

Kaji-ichigoside F1 (KF1), a natural oleanane-type triterpenoid saponin, is the main active constituent from

Indexed as

Neuroprotective AgentsProto-Oncogene Proteins c-aktAnimalsBrain-Derived Neurotrophic FactorMiceNeuroprotectionN-MethylaspartateRatsReceptors, N-Methyl-D-AspartateSignal TransductionTOR Serine-Threonine KinasesBrain-Derived Neurotrophic FactormTOR protein, ratNeuroprotective AgentsN-MethylaspartateProto-Oncogene Proteins c-aktReceptors, N-Methyl-D-AspartateTOR Serine-Threonine KinasesBDNF/AKT/mTORkaji-ichigoside F1neuroprotectionNMDA-induced neurotoxicityRosa roxburghii

Identifiers

PMID36555790
PMCPMC9785992
OpenAlexW4312210092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.