Evidence map›Paper›PMID 36555682›Full record

ArticleInternational journal of molecular sciences2022

Substrate Recognition Properties from an Intermediate Structural State of the UreA Transporter.

Manuel Sanguinetti, Lucianna Helene Silva Santos, Juliette Dourron, Catalina Alamón, Juan Idiarte, Sotiris Amillis, Sergio Pantano, Ana Ramón

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Inverse PCR for Site-Directed Mutagenesis.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Manuel SanguinettiSección Bioquímica, Departamento de Biología Celular y Molecular, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo 11400, Uruguay.
Lucianna Helene Silva SantosBiomolecular Simulations Group, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay.ORCID 0000-0002-6910-0697
Juliette DourronSección Bioquímica, Departamento de Biología Celular y Molecular, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo 11400, Uruguay.ORCID 0000-0003-3236-5146
Catalina AlamónSección Bioquímica, Departamento de Biología Celular y Molecular, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo 11400, Uruguay.
Juan IdiarteSección Bioquímica, Departamento de Biología Celular y Molecular, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo 11400, Uruguay.ORCID 0000-0003-3908-2747
Sotiris AmillisDepartment of Biology, National and Kapodistrian University of Athens, Panepistimioupolis, 15784 Athens, Greece.
Sergio PantanoBiomolecular Simulations Group, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay.ORCID 0000-0001-6435-4543
Ana RamónSección Bioquímica, Departamento de Biología Celular y Molecular, Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo 11400, Uruguay.ORCID 0000-0001-6810-6184
Universidad de la República de Uruguay · UYInstitut Pasteur de Montevideo · UYNational and Kapodistrian University of Athens · GR

Funding

ANII FCE_3_2018_1_148002FOCEM (MERCOSUR Structural Convergence 556 Fund COF 03/11PEDECIBA Biología
6 · The paper itself

Abstract

Through a combination of comparative modeling, site-directed and classical random mutagenesis approaches, we previously identified critical residues for binding, recognition, and translocation of urea, and its inhibition by 2-thiourea and acetamide in the

Indexed as

Artificial IntelligenceFurylfuramideAcetamidesMolecular Docking SimulationThioureaUreaUrea TransportersAcetamidesFurylfuramideThioureaUreaUrea TransportersAlphaFold2Aspergillus nidulansbinding sitemolecular dockingurea transport

Identifiers

PMID36555682
PMCPMC9783183
OpenAlexW4312194858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.