Evidence map›Paper›PMID 36555655›Full record

ArticleInternational journal of molecular sciences2022

Anti-SOD1 Nanobodies That Stabilize Misfolded SOD1 Proteins Also Promote Neurite Outgrowth in Mutant SOD1 Human Neurons.

Meenakshi Sundaram Kumar, Megan E Fowler-Magaw, Daniel Kulick, Sivakumar Boopathy, Del Hayden Gadd, Melissa Rotunno, Catherine Douthwright, Diane Golebiowski, Issa Yusuf, Zuoshang Xu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Meenakshi Sundaram KumarDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Megan E Fowler-MagawDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-3774-3137
Daniel KulickDepartment of Biology, Neuroscience and Behavior Program, Wesleyan University, Middletown, CT 06459, USA.
Sivakumar BoopathyDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0003-0524-3338
Del Hayden GaddDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-8279-7065
Melissa RotunnoDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Catherine DouthwrightDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Diane GolebiowskiDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-5550-7883
Issa YusufDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Zuoshang XuDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Robert H BrownDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Miguel Sena-EstevesDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Alison L O'NeilDepartment of Chemistry, Neuroscience and Behavior Program, Wesleyan University, Middletown, CT 06459, USA.ORCID 0000-0002-0759-4740
Daryl A BoscoDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
University of Massachusetts Chan Medical School · USWesleyan University · US

Funding

University of Massachusetts Center for Clinical Science and Translational SupplementUL1TR001453 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2015 to 2024
$39.0M
Multimodal analysis and therapeutic targeting of aberrant nucleocytoplasmic compartmentalization in FUS-related neurodegenerative diseaseR01NS108769 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Daryl Angela Bosco, Ankur Jain · 2019 to 2026
$5.2M
Protein Arginine Deiminase 2 (PAD2) and Protein Citrullination in ALSR01NS118145 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI XU, ZUOSHANG · 2021 to 2025
$2.4M
Impact of ALS-linked mutations on the structure, dynamics and function of profilin-1R01GM137529 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOSCO, DARYL ANGELA, MASSI, FRANCESCA · 2021 to 2024
$2.1M
An in vivo approach to understanding mutant PFN1 toxicity on motor neuronsR01NS101895 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI XU, ZUOSHANG · 2017 to 2021
$1.8M
Residue-by-residue details of FUS protein phase separation and aggregationR01GM147677 · NIGMS · BROWN UNIVERSITY · PI FAWZI, NICOLAS LUX · 2022 to 2025
$1.7M
Investigation of post-translational modifications in WT SOD1 in sporadic ALSR01NS067206 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOSCO, DARYL ANGELA · 2010 to 2013
$1.4M
Role of p38alpha signaling in mutant SOD1-linked motor neuron diseaseR21NS120126 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BOSCO, DARYL ANGELA, MORFINI, GERARDO ANDRES · 2020 to 2020
$458k
NCATS NIH HHS UL1 TR001453NIGMS NIH HHS R01 GM137529NIGMS NIH HHS R01 GM147677NINDS NIH HHS R01 NS067206NINDS NIH HHS R01 NS101895NINDS NIH HHS R01 NS108769NINDS NIH HHS R01 NS118145NINDS NIH HHS R21 NS120126
6 · The paper itself

Abstract

ALS-linked mutations induce aberrant conformations within the SOD1 protein that are thought to underlie the pathogenic mechanism of SOD1-mediated ALS. Although clinical trials are underway for gene silencing of

Indexed as

Amyotrophic Lateral SclerosisSingle-Domain AntibodiesAnimalsHumansMiceMotor NeuronsMutationNeuronal OutgrowthProtein FoldingSuperoxide DismutaseSuperoxide Dismutase-1Single-Domain AntibodiesSOD1 protein, humanSuperoxide DismutaseSuperoxide Dismutase-1amyotrophic lateral sclerosis (ALS) (Lou Gehrig disease)antibody engineeringneurite outgrowthprotein misfoldingsuperoxide dismutase (SOD)

Identifiers

PMID36555655
PMCPMC9784173
OpenAlexW4312195366

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.