Characterisation of the Molecular Mechanism of Permeation of the Prodrug Me-5ALA across the Human

Janonna Kadyrov, Lanie Ruiz-Perez, Heather A E Benson, Ricardo L Mancera

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 63% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Janonna KadyrovCurtin Medical School, Curtin Health Innovation Research Institute and Curtin Institute for Computation, Curtin University, GPO Box U1987, Perth, WA 5845, Australia.ORCID 0000-0002-5259-7465

Lanie Ruiz-PerezCurtin Medical School, Curtin Health Innovation Research Institute and Curtin Institute for Computation, Curtin University, GPO Box U1987, Perth, WA 5845, Australia.

Heather A E BensonCurtin Medical School, Curtin Health Innovation Research Institute and Curtin Institute for Computation, Curtin University, GPO Box U1987, Perth, WA 5845, Australia.ORCID 0000-0002-1818-5627

Ricardo L ManceraCurtin Medical School, Curtin Health Innovation Research Institute and Curtin Institute for Computation, Curtin University, GPO Box U1987, Perth, WA 5845, Australia.ORCID 0000-0002-9191-5622

Curtin University · AUUniversity of South Australia · AU

Funding

Curtin University Curtin International Postgraduate Research Scholarship

6 · The paper itself

Abstract

The barrier imposed by the outer layer of the skin, the

Indexed as

ProdrugsAdministration, CutaneousHumansMolecular Dynamics SimulationPermeabilitySkinSkin AbsorptionProdrugsdrug lipidationdrug permeationlipid bilayerprodrugtransdermal drug delivery

Identifiers

PMID36555643

DOI10.3390/ijms232416001

PMCPMC9786775

OpenAlexW4312210694

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.