Evidence map›Paper›PMID 36555641›Full record

ArticleInternational journal of molecular sciences2022

Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists.

Francesca Curreli, Young D Kwon, Isabella Nicolau, Giancarla Burgos, Andrea Altieri, Alexander V Kurkin, Raffaello Verardi, Peter D Kwong, Asim K Debnath

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Progress of the "Molecular Informatics" Section in 2022.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesca CurreliLaboratory of Molecular Modeling and Drug Design, Lindsey F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
Young D KwonVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Isabella NicolauLaboratory of Molecular Modeling and Drug Design, Lindsey F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
Giancarla BurgosLaboratory of Molecular Modeling and Drug Design, Lindsey F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
Andrea AltieriEDASA Scientific srls, Via Stingi 37, 66050 San Salvo, Italy.ORCID 0000-0002-9815-9866
Alexander V KurkinEDASA Scientific srls, Via Stingi 37, 66050 San Salvo, Italy.
Raffaello VerardiVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Peter D KwongVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Asim K DebnathLaboratory of Molecular Modeling and Drug Design, Lindsey F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.ORCID 0000-0003-2761-0506

Funding

Design of inhibitors targeted to the CD4 binding site on HIV-1 gp120R01AI104416 · NIAID · NEW YORK BLOOD CENTER · PI DEBNATH, ASIM K · 2013 to 2022
$7.9M
NIH HHS R01 AI104416
6 · The paper itself

Abstract

As part of our effort to discover drugs that target HIV-1 entry, we report the antiviral activity and crystal structures of two novel inhibitors in a complex with a gp120 core. NBD-14204 showed similar antiviral activity against all the clinical isolates tested. The IC

Indexed as

Anti-HIV AgentsHIV-1CD4 AntigensHIV Envelope Protein gp120ThiazolesAnti-HIV AgentsCD4 AntigensHIV Envelope Protein gp120Thiazolesantiviralcrystal structurecytotoxicityenvelope glycoprotein (Env)gp120 antagonistHIV-1

Identifiers

PMID36555641
PMCPMC9784924

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.