Evidence map›Paper›PMID 36555639›Full record

ArticleInternational journal of molecular sciences2022

The Reactions of N,N'-Diphenyldithiomalondiamide with Arylmethylidene Meldrum's Acids.

Victor V Dotsenko, Alexander V Aksenov, Anna E Sinotsko, Ekaterina A Varzieva, Alena A Russkikh, Arina G Levchenko, Nicolai A Aksenov, Inna V Aksenova

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In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Victor V DotsenkoDepartment of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya St., 350040 Krasnodar, Russia.ORCID 0000-0001-7163-0497
Alexander V AksenovDepartment of Organic Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.ORCID 0000-0002-6644-9949
Anna E SinotskoDepartment of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya St., 350040 Krasnodar, Russia.
Ekaterina A VarzievaDepartment of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya St., 350040 Krasnodar, Russia.ORCID 0000-0002-3204-8995
Alena A RusskikhDepartment of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya St., 350040 Krasnodar, Russia.
Arina G LevchenkoDepartment of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya St., 350040 Krasnodar, Russia.
Nicolai A AksenovDepartment of Organic Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
Inna V AksenovaDepartment of Organic Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.

Funding

Russian Science Foundation 22-23-00458
6 · The paper itself

Abstract

The Michael addition reaction between dithiomalondianilide (N,N'-diphenyldithiomalondiamide) and arylmethylidene Meldrum's acids, accompanied by subsequent heterocyclization, was investigated along with factors affecting the mixture composition of the obtained products. The plausible mechanism includes the formation of stable Michael adducts which, under the studied conditions, undergo further transformations to yield corresponding N-methylmorpholinium 4-aryl-6-oxo-3-(N-phenylthio-carbamoyl)-1,4,5,6-tetrahydropyridin-2-thiolates and their oxidation derivatives, 4,5-dihydro-3H-[1,2]dithiolo[3,4-b]pyridin-6(7H)-ones. The structure of one such product, N-methylmorpholinium 2,2-dimethyl-5-(1-(2-nitrophenyl)-3-(phenylamino)-2-(N-phenylthiocarbamoyl)-3-thioxopropyl)-4-oxo-4H-1,3-dioxin-6-olate, was confirmed via X-ray crystallography.

Indexed as

DioxanesOxidation-ReductionDioxanesactive methylene compoundsdithiomalonamidesheterocyclizationMeldrum’s acidMichael adducts

Identifiers

PMID36555639
PMCPMC9785638

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.