ArticleInternational journal of molecular sciences2022
Functional and Taxonomic Traits of the Gut Microbiota in Type 1 Diabetes Children at the Onset: A Metaproteomic Study.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Are Bifidobacterium Species Key Players in the Progression of Type 1 Diabetes? A Systematic Review.Endocrinology, diabetes & metabolism · 2025Pooled it
- Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk.Nature metabolism · 2026Article
- [Gut microbiota dysbiosis in type 1 diabetes mellitus: Impacts, mechanisms, and interventions].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- Bacteria and phage consortia modulate cecal SCFA production and host metabolism to enhance feed efficiency in ducks.Microbiome · 2026Article
- Recent advances in the positive role ofFrontiers in immunology · 2026Review
- The role of the gut microbiota during the first 2 years of life in the early programming of obesity, type 2 diabetes, and hypertension.Frontiers in nutrition · 2026Review
- Metaproteomics reveals diet-induced changes in gut microbiome function according to Crohn's disease location.Microbiome · 2024Article
- A novel clinical metaproteomics workflow enables bioinformatic analysis of host-microbe dynamics in disease.mSphere · 2024Article
- Williams-Beuren syndrome shapes the gut microbiota metaproteome.Scientific reports · 2023Article
- Autoimmune diseases and gut microbiota: a bibliometric and visual analysis from 2004 to 2022.Clinical and experimental medicine · 2023Article
- Editorial of Special Issues "Gut Microbiota-Host Interactions: From Symbiosis to Dysbiosis 2.0".International journal of molecular sciences · 2023Article
- Association between Gut Dysbiosis and the Occurrence of SIBO, LIBO, SIFO and IMO.Microorganisms · 2023Review
- The metaproteome of the gut microbiota in pediatric patients affected by COVID-19.Frontiers in cellular and infection microbiology · 2023Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 1 diabetes (T1D) is a chronic autoimmune metabolic disorder with onset in pediatric/adolescent age, characterized by insufficient insulin production, due to a progressive destruction of pancreatic β-cells. Evidence on the correlation between the human gut microbiota (GM) composition and T1D insurgence has been recently reported. In particular, 16S rRNA-based metagenomics has been intensively employed in the last decade in a number of investigations focused on GM representation in relation to a pre-disease state or to a response to clinical treatments. On the other hand, few works have been published using alternative functional omics, which is more suitable to provide a different interpretation of such a relationship. In this work, we pursued a comprehensive metaproteomic investigation on T1D children compared with a group of siblings (SIBL) and a reference control group (CTRL) composed of aged matched healthy subjects, with the aim of finding features in the T1D patients' GM to be related with the onset of the disease. Modulated metaproteins were found either by comparing T1D with CTRL and SIBL or by stratifying T1D by insulin need (IN), as a proxy of β-cells damage, showing some functional and taxonomic traits of the GM, possibly related to the disease onset at different stages of severity.
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