ArticleInternational journal of molecular sciences2022
Solubility Enhancement of Dihydroquercetin via "Green" Phase Modification.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Co-Amorphous Systems Based on Dihydroquercetin and l-Lysine: Synthesis and Evaluation.Pharmaceutics · 2025Article
- Modern Developing Directions in the Dihydroquercetin Study.Molecules (Basel, Switzerland) · 2025Review
- Plant Extracts as Modulators of the Wound Healing Process-Preliminary Study.International journal of molecular sciences · 2025Article
- Dihydroquercetin and Related Flavonoids in Antioxidant Formulations with α-Tocopherol.International journal of molecular sciences · 2025Article
- Insights in wound healing properties of water-soluble composition of dihydroquercetin and L-lysine.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2025Article
- Modification of biopharmaceutical parameters of flavonoids: a review.Frontiers in chemistry · 2025Review
- Modification of the Physicochemical Properties of Active Pharmaceutical Ingredients via Lyophilization.Pharmaceutics · 2023Review
- Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats.International journal of molecular sciences · 2023Article
- Dihydroquercetin/Taxifolin Inhibits METTL3/mKidney diseases (Basel, Switzerland)Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dihydroquercetin (DHQ) is a promising antioxidant for medical applications. The poor water solubility of this flavanonol at ambient conditions inhibits its implementation in clinical practice as an injectable dosage form. Thus, increasing water solubility is a critical step toward solving this problem. Herein we attempted to deal with this problem via DHQ phase modification while at the same time adhering to the principles of green chemistry as much as possible. Lyophilization is an appropriate method to achieve phase modification in an environment-friendly way. This method was employed to generate new phase modifications of DHQ that were then characterized. Mixtures of water with ethanol or acetonitrile were used as solvents for the preparation of the lyophilizates, DHQ
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.