Evidence map›Paper›PMID 36555507›Full record

ArticleInternational journal of molecular sciences2022

Molecular Fingerprint of Human Pathological Synoviocytes in Response to Extractive Sulfated and Biofermentative Unsulfated Chondroitins.

Valentina Vassallo, Antonietta Stellavato, Rosita Russo, Donatella Cimini, Mariangela Valletta, Alberto Alfano, Paolo Vincenzo Pedone, Angela Chambery, Chiara Schiraldi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Valentina VassalloDepartment of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-6891-9724
Antonietta StellavatoDepartment of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0003-1635-2724
Rosita RussoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.ORCID 0000-0002-2235-6302
Donatella CiminiDepartment of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-4961-8819
Mariangela VallettaDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.
Alberto AlfanoDepartment of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Paolo Vincenzo PedoneDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.
Angela ChamberyDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.ORCID 0000-0002-5136-0941
Chiara SchiraldiDepartment of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1066-843X
University of Campania "Luigi Vanvitelli" · IT

Funding

Italian Ministry of Development and economical development (MISE) InCubeItalian Ministry of University and research PON03PE_00060_3
6 · The paper itself

Abstract

Pharma-grade extractive chondroitin sulfate (CS) is widely used for osteoarthritis (OA) treatment. Recently, unsulfated biofermentative chondroitin (BC) proved positive effects in OA in vitro model. This study, based on primary pathological human synoviocytes, aimed to analyze, by a multiplex assay, a panel of OA-related biomarkers in response to short-term treatments with bovine (CS

Indexed as

OsteoarthritisSynoviocytesAnimalsBiomarkersCattleChondroitin SulfatesHumansProteomicsSulfatesSwineTandem Mass SpectrometryBiomarkersChondroitin SulfatesSulfatesbiofermentative unsulfated chondroitinextractive chondroitin sulfatehuman primary synoviocytesintracellular proteomic

Identifiers

PMID36555507
PMCPMC9784855
OpenAlexW4311357410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.