Evidence map›Paper›PMID 36555419›Full record

ReviewInternational journal of molecular sciences2022

Key Characteristics and Development of Psychoceuticals: A Review.

Genaro Herrera Cano, Jordan Dean, Samuel Padilla Abreu, Amanda Hernández Rodríguez, Cyrena Abbasi, Madison Hinson, Brandon Lucke-Wold

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Genaro Herrera CanoUniversity of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030, USA.
Jordan DeanUniversity of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030, USA.ORCID 0000-0002-7914-0246
Samuel Padilla AbreuUniversity of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030, USA.
Amanda Hernández RodríguezUniversity of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030, USA.
Cyrena AbbasiUniversity of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030, USA.
Madison HinsonWake Forest University School of Medicine, 475 Vine St, Winston-Salem, NC 27101, USA.
Brandon Lucke-WoldDepartment of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.ORCID 0000-0001-6577-4080
University of Connecticut · USUniversity of Florida · USWake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychoceuticals have brought benefits to the pharmacotherapeutic management of central nervous system (CNS) illnesses since the 19th century. However, these drugs have potential side effects or lack high response rates. This review covers twenty drugs' biochemical mechanisms, benefits, risks, and clinical trial reports. For this study, medications from seven psychoceutical organizations were reviewed and evaluated. Nineteen drugs were chosen from the organizations, and one was selected from the literature. The databases used for the search were Pubmed, Google Scholar, and NIH clinical trials. In addition, information from the organizations' websites and other sources, such as news reports, were also used. From the list of drugs, the most common targets were serotonergic, opioid, and N-methyl-D-aspartate (NMDA) receptors. These drugs have shown promise in psychiatric illnesses such as substance abuse, post-traumatic stress disorder (PTSD), anxiety, depression, and neurological conditions, such as Parkinson's disease, traumatic brain injury, and neuroinflammation. Some of these drugs, however, are still early in development, so their therapeutic significance cannot be determined. These twenty drugs have promising benefits, but their clinical usage and efficacy must still be explored.

Indexed as

Parkinson DiseaseStress Disorders, Post-TraumaticAnxietyAnxiety DisordersHumansemerging treatmentimproved outcomesneurointerventionpharmacotherapypsychoceutical

Identifiers

PMID36555419
PMCPMC9779201
OpenAlexW4312194747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.