Evidence map›Paper›PMID 36555389›Full record

ArticleInternational journal of molecular sciences2022

Gene Expression Linked to Reepithelialization of Human Skin Wounds.

Magnus S Ågren, Thomas Litman, Jens Ole Eriksen, Peter Schjerling, Michael Bzorek, Lise Mette Rahbek Gjerdrum

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  6. Sea CucumberMarine drugs · 2025
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  13. Article
  14. Review
  15. Article
  16. Matrix Metalloproteinases on Skin Photoaging.Journal of cosmetic dermatology · 2024
    Review
  17. Review
  18. Article
  19. Observational
  20. [Role of Fibroblast Growth Factor 7 in Craniomaxillofacial Development].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Magnus S ÅgrenDepartment of Dermatology and Copenhagen Wound Healing Center, Bispebjerg Hospital, University of Copenhagen, 2400 Copenhagen, Denmark.ORCID 0000-0002-2263-0826
Thomas LitmanDepartment of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-6068-901X
Jens Ole EriksenDepartment of Pathology, Zealand University Hospital, 4000 Roskilde, Denmark.
Peter SchjerlingInstitute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital-Bispebjerg-Frederiksberg, 2400 Copenhagen, Denmark.ORCID 0000-0001-7138-3211
Michael BzorekDepartment of Pathology, Zealand University Hospital, 4000 Roskilde, Denmark.
Lise Mette Rahbek GjerdrumDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0003-4377-3209
University of Copenhagen · DKZealand University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our understanding of the regulatory processes of reepithelialization during wound healing is incomplete. In an attempt to map the genes involved in epidermal regeneration and differentiation, we measured gene expression in formalin-fixed, paraffin-embedded standardized epidermal wounds induced by the suction-blister technique with associated nonwounded skin using NanoString technology. The transcripts of 139 selected genes involved in clotting, immune response to tissue injury, signaling pathways, cell adhesion and proliferation, extracellular matrix remodeling, zinc transport and keratinocyte differentiation were evaluated. We identified 22 upregulated differentially expressed genes (DEGs) in descending order of fold change (

Indexed as

Gene ExpressionSkinWounds and InjuriesFibroblastsHumansKeratinocytesRNA, MessengerRNA, Messengercytokinesfibroblastsgene expressionkeratinocytesmatrix metalloproteinaseswound healing

Identifiers

PMID36555389
PMCPMC9779194
OpenAlexW4311154746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.