Evidence map›Paper›PMID 36555366›Full record

ArticleInternational journal of molecular sciences2022

Pancreatic Secretory Trypsin Inhibitor (SPINK1) Gene Mutation in Patients with Acute Alcohol Pancreatitis (AAP) Compared to Healthy Controls and Heavy Alcohol Users without Pancreatitis.

Anssi Nikkola, Kari Antero Mäkelä, Karl-Heinz Herzig, Shivaprakash Jagalur Mutt, Aishwarya Prasannan, Hanna Seppänen, Terho Lehtimäki, Mika Kähönen, Olli Raitakari, Ilkka Seppälä and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Anssi NikkolaDepartment of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, 33520 Tampere, Finland.
Kari Antero MäkeläResearch Unit of Biomedicine, Oulu University, 90220 Oulu, Finland.
Karl-Heinz HerzigResearch Unit of Biomedicine, Oulu University, 90220 Oulu, Finland.ORCID 0000-0003-4460-2604
Shivaprakash Jagalur MuttResearch Unit of Biomedicine, Oulu University, 90220 Oulu, Finland.ORCID 0000-0001-8285-551X
Aishwarya PrasannanResearch Unit of Biomedicine, Oulu University, 90220 Oulu, Finland.
Hanna SeppänenDepartment of Surgery, Helsinki University Hospital, 00260 Helsinki, Finland.
Terho LehtimäkiFaculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.
Mika KähönenFaculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.
Olli RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, 20521 Turku, Finland.
Ilkka SeppäläFimlab Laboratories, Department of Clinical Chemistry, 33520 Tampere, Finland.
Pihla PakkanenFaculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.
Isto NordbackFaculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.
Juhani SandDepartment of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, 33520 Tampere, Finland.
Johanna LaukkarinenDepartment of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, 33520 Tampere, Finland.
Tampere University · FIUniversity of Oulu · FIFimlab (Finland) · FIHelsinki University Hospital · FIPoznan University of Medical Sciences · PLTampere University Hospital · FIUniversity of Turku · FI

Funding

Competitive State Research Funding of the Expert Responsibility Area of Tampere University Hospital 9U028, 9V028, 9X024, 9AA039Sigrid Jusélius Foundation SAT113
6 · The paper itself

Abstract

Only 3-5% of heavy alcohol users develop acute alcohol pancreatitis (AAP). This suggests that additional triggers are required to initiate the inflammatory process. Genetic susceptibility contributes to the development of AAP, and SPINK1 mutation is a documented risk factor. We investigated the prevalence of the SPINK1(N34S) mutation in patients with AAP compared to heavy alcohol users who had never suffered an episode of pancreatitis. Blood samples for the mutational analysis from patients with first episode (

Indexed as

Alcohol DrinkingPancreatitisTrypsin Inhibitor, Kazal PancreaticGenetic Predisposition to DiseaseHumansMutationRisk FactorsTrypsinSPINK1 protein, humanTrypsinTrypsin Inhibitor, Kazal Pancreaticacute alcohol pancreatitisalcoholicsgenesgeneticsserine protease inhibitor Kazal-type 1SPINK1

Identifiers

PMID36555366
PMCPMC9778821
OpenAlexW4312123970

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.