Evidence map›Paper›PMID 36555333›Full record

ArticleInternational journal of molecular sciences2022

Synthesis, Structural Characterization and Biological Activity Evaluation of Novel Cu(II) Complexes with 3-(trifluoromethyl)phenylthiourea Derivatives.

Aleksandra Drzewiecka-Antonik, Marta Struga, Agnieszka Głogowska, Ewa Augustynowicz-Kopec, Katarzyna Dobrzyńska, Alicja Chrzanowska, Anna Wolska, Paweł Rejmak, Marcin T Klepka, Małgorzata Wrzosek and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aleksandra Drzewiecka-AntonikInstitute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, PL-02668 Warsaw, Poland.
Marta StrugaChair and Department of Biochemistry, Medical University of Warsaw, Banacha 1, PL-02097 Warsaw, Poland.ORCID 0000-0002-0181-3607
Agnieszka GłogowskaInstitute of Tuberculosis and Lung Diseases, Microbiology Department, Plocka 26, PL-01138 Warsaw, Poland.ORCID 0000-0003-1296-4934
Ewa Augustynowicz-KopecInstitute of Tuberculosis and Lung Diseases, Microbiology Department, Plocka 26, PL-01138 Warsaw, Poland.ORCID 0000-0001-6162-8748
Katarzyna DobrzyńskaDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Warsaw Medical University, 3 Oczki Street, PL-02007 Warsaw, Poland.
Alicja ChrzanowskaChair and Department of Biochemistry, Medical University of Warsaw, Banacha 1, PL-02097 Warsaw, Poland.
Anna WolskaInstitute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, PL-02668 Warsaw, Poland.ORCID 0000-0003-4621-9561
Paweł RejmakInstitute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, PL-02668 Warsaw, Poland.ORCID 0000-0002-0535-2107
Marcin T KlepkaInstitute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, PL-02668 Warsaw, Poland.
Małgorzata WrzosekDepartment of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, PL-02097 Warsaw, Poland.ORCID 0000-0002-9820-3871
Anna BielenicaChair and Department of Biochemistry, Medical University of Warsaw, Banacha 1, PL-02097 Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper complexes with 1,3-disubstituted thiourea derivatives, all containing 3-(trifluoromethyl)phenyl tail and 1-alkyl/halogen-phenyl substituent, were synthesized. The experimental spectroscopic studies and theoretical calculation revealed that two ligands coordinate to Cu(II) in a bidentate fashion via thiocarbonyl S and deprotonated N atoms of thiourea moiety. Such monomers are characteristic of alkylphenylthiourea complexes, whereas the formation of a sandwich-type dimer is observed for halogeno derivatives. For the first time, the structural identifications of CuN

Indexed as

Coordination ComplexesPhenylthioureaAnti-Bacterial AgentsCopperDNA GyraseDNA Topoisomerase IVHumansThioureaAnti-Bacterial AgentsCoordination ComplexesCopperDNA GyraseDNA Topoisomerase IVPhenylthioureaThioureaantimicrobial activityATR-IRCu(II) complexesthioureaUV-VisXAFS

Identifiers

PMID36555333
PMCPMC9779606

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.