Altered GABA

Muhammad Hassan, Nadia K Adotevi, Beulah Leitch

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.4field-weighted citation impact, top 45% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

Molecular Mechanisms Underlying the Generation of Absence Seizures: Identification of Potential Targets for Therapeutic Intervention.International journal of molecular sciences · 2024
Review
Developmental Inhibitory Changes in the Primary Somatosensory Cortex of the Stargazer Mouse Model of Absence Epilepsy.Biomolecules · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Muhammad HassanDepartment of Anatomy, School of Biomedical Sciences, and the Brain Health Research Centre, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand.

Nadia K AdoteviDepartment of Anatomy, School of Biomedical Sciences, and the Brain Health Research Centre, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand.

Beulah LeitchDepartment of Anatomy, School of Biomedical Sciences, and the Brain Health Research Centre, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand.

University of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Absence seizures are hyperexcitations within the cortico-thalamocortical (CTC) network, however the underlying causative mechanisms at the cellular and molecular level are still being elucidated and appear to be multifactorial. Dysfunctional feed-forward inhibition (FFI) is implicated as one cause of absence seizures. Previously, we reported altered excitation onto parvalbumin-positive (PV

Indexed as

Epilepsy, AbsenceAnimalsDisease Models, Animalgamma-Aminobutyric AcidMiceReceptors, GABA-ASeizuresSomatosensory Cortexgamma-Aminobutyric AcidReceptors, GABA-Aabsence epilepsybiochemical fractionationcortico-thalamocortical networkGABAA receptorsimmunogold-cytochemistry electron microscopyprimary somatosensory cortexstargazer mouseWestern blotting

Identifiers

PMID36555327

DOI10.3390/ijms232415685

PMCPMC9778655

OpenAlexW4312123290

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.