Evidence map›Paper›PMID 36555307›Full record

ArticleInternational journal of molecular sciences2022

Lung Organoids for Hazard Assessment of Nanomaterials.

Miriam T Kastlmeier, Eva M Guenther, Tobias Stoeger, Carola Voss

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Bionic breathing-type airway exposure system for inhalation exposure studies.Frontiers in bioengineering and biotechnology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Twenty years ofFrontiers in toxicology · 2024
    Article
  9. Cytokine signaling converging onFrontiers in immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Miriam T KastlmeierInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center Munich (CPC-M), Helmholtz Center Munich, Research Center for Environmental Health, 85764 München, Germany.
Eva M GuentherInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center Munich (CPC-M), Helmholtz Center Munich, Research Center for Environmental Health, 85764 München, Germany.
Tobias StoegerInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center Munich (CPC-M), Helmholtz Center Munich, Research Center for Environmental Health, 85764 München, Germany.
Carola VossInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center Munich (CPC-M), Helmholtz Center Munich, Research Center for Environmental Health, 85764 München, Germany.ORCID 0000-0001-5243-4415
Helmholtz Zentrum München · DE

Funding

European Union's Horizon 2020 No 953183
6 · The paper itself

Abstract

Lung epithelial organoids for the hazard assessment of inhaled nanomaterials offer a promising improvement to in vitro culture systems used so far. Organoids grow in three-dimensional (3D) spheres and can be derived from either induced pluripotent stem cells (iPSC) or primary lung tissue stem cells from either human or mouse. In this perspective we will highlight advantages and disadvantages of traditional culture systems frequently used for testing nanomaterials and compare them to lung epithelial organoids. We also discuss the differences between tissue and iPSC-derived organoids and give an outlook in which direction the whole field could possibly go with these versatile tools.

Indexed as

Induced Pluripotent Stem CellsLungAnimalsCell DifferentiationHumansMiceOrganoids3D in vitro modelshazard assessmentnanomaterialorganoidspluripotent stem cellspulmonary particle exposurerespiratory toxicity

Identifiers

PMID36555307
PMCPMC9779559
OpenAlexW4312194478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.