Evidence map›Paper›PMID 36555294›Full record

ArticleInternational journal of molecular sciences2022

Inhibition of

Ana H Sales, Vincent Zheng, Maya A Kenawy, Mark Kakembo, Lu Zhang, Vladimir Shafirovich, Suse Broyde, Nicholas E Geacintov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ana H SalesChemistry Department, New York University, 31 Washington Place, New York, NY 10003-5180, USA.ORCID 0000-0002-4697-3938
Vincent ZhengChemistry Department, New York University, 31 Washington Place, New York, NY 10003-5180, USA.ORCID 0000-0002-8232-3190
Maya A KenawyChemistry Department, New York University, 31 Washington Place, New York, NY 10003-5180, USA.
Mark KakemboChemistry Department, New York University, 31 Washington Place, New York, NY 10003-5180, USA.
Lu ZhangDivision of Arts and Sciences, NYU Shanghai, 1555 Century Avenue, Shanghai 200122, China.
Vladimir ShafirovichChemistry Department, New York University, 31 Washington Place, New York, NY 10003-5180, USA.
Suse BroydeDepartment of Biology, New York University, 31 Washington Place, New York, NY 10003-5180, USA.
Nicholas E GeacintovChemistry Department, New York University, 31 Washington Place, New York, NY 10003-5180, USA.ORCID 0000-0002-7961-2231
New York University · USNew York University Shanghai · CN

Funding

Environmental DNA Lesions and Mutagenesis: Molecular Mechanisms of Lesion Recognition for Repair and Polymerase BypassR01ES025987 · NIEHS · NEW YORK UNIVERSITY · PI BROYDE, SUSE · 2016 to 2025
$3.6M
Excision of Carcinogen-DNA Adducts in NucleosomesR01CA168469 · NCI · NEW YORK UNIVERSITY · PI GEACINTOV, NICHOLAS E · 2012 to 2016
$1.6M
Funding for open access charge: National Institutes of Environmental Health Sciences Grants R01-ES025987national institutes of environmental health sciences R01-ES025987National Institutes of Environmental Health Sciences R01-ES024050NCI NIH HHS R01-CA168469NIEHS NIH HHS R01 ES025987
6 · The paper itself

Abstract

DNA helicase unwinding activity can be inhibited by small molecules and by covalently bound DNA lesions. Little is known about the relationships between the structural features of DNA lesions and their impact on unwinding rates and processivities. Employing

Indexed as

Escherichia coliRecQ HelicasesDNADNA AdductsGuanineStructure-Activity RelationshipDNADNA AdductsGuanineRecQ HelicasesRecQ protein, E colibenzo[a]pyene diol epoxide-DNA adductsCPD and (6-4) thymine dimersprocessivitiesRecQ helicasespiroiminodihydantoinunwinding

Identifiers

PMID36555294
PMCPMC9779537
OpenAlexW4312123489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.