Evidence map›Paper›PMID 36555252›Full record

ArticleInternational journal of molecular sciences2022

Isogenic Human-Induced Pluripotent Stem-Cell-Derived Cardiomyocytes Reveal Activation of Wnt Signaling Pathways Underlying Intrinsic Cardiac Abnormalities in Rett Syndrome.

Kwong-Man Ng, Qianqian Ding, Yiu-Lam Tse, Oscar Hou-In Chou, Wing-Hon Lai, Ka-Wing Au, Yee-Man Lau, Yue Ji, Chung-Wah Siu, Clara Sze-Man Tang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Kwong-Man NgCardiology Division, Department of Medicine, Li Ka-Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Qianqian DingSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yiu-Lam TseCardiology Division, Department of Medicine, Li Ka-Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Oscar Hou-In ChouCardiology Division, Department of Medicine, Li Ka-Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0001-7058-4708
Wing-Hon LaiCardiology Division, Department of Medicine, Li Ka-Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Ka-Wing AuCardiology Division, Department of Medicine, Li Ka-Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Yee-Man LauCardiology Division, Department of Medicine, Li Ka-Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Yue JiDepartment of Surgery, Li Ka-Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Chung-Wah SiuCardiology Division, Department of Medicine, Li Ka-Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Clara Sze-Man TangDepartment of Surgery, Li Ka-Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0003-0265-2638
Alan ColmanHarvard Department of Stem Cells and Regenerative Biology, Cambridge, MA 02138, USA.
Suk-Ying TsangSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Hung-Fat TseCenter for Translational Stem Cell Biology, Hong Kong SAR, China.
Chinese University of Hong Kong · HKGuangzhou Institutes of Biomedicine and Health · CNHarvard Stem Cell Institute · US

Funding

Food and Health bureau, Hong Kong EH 472/1-1Research grant council, Hong Kong 17111320 and 17106917
6 · The paper itself

Abstract

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by

Indexed as

Induced Pluripotent Stem CellsRett SyndromeCell LineFemaleHumansMethyl-CpG-Binding Protein 2MutationMyocytes, CardiacWnt Signaling PathwayMethyl-CpG-Binding Protein 2intrinsic cardiac abnormalityMeCP2 mutationRett syndromeWnt/β-catenin signaling pathway

Identifiers

PMID36555252
PMCPMC9779632
OpenAlexW4311968037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.