Evidence map›Paper›PMID 36555238›Full record

ArticleInternational journal of molecular sciences2022

Anti-Inflammatory Effect of the Natural H

Valerio Ciccone, Eugenia Piragine, Era Gorica, Valentina Citi, Lara Testai, Eleonora Pagnotta, Roberto Matteo, Nicola Pecchioni, Rosangela Montanaro, Lorenzo Di Cesare Mannelli and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Glucosinolate Derivatives: Emerging Anti-Inflammatory Agents.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  6. Article
  7. Naturally Occurring HHandbook of experimental pharmacology · 2026
    Review
  8. Review
  9. Transsulfuration Pathway Products and HInternational journal of molecular sciences · 2025
    Review
  10. Review
  11. Studying Nitric Oxide in Endothelial Cells.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  12. Article
  13. Erucin, a Natural Isothiocyanate, Prevents Polyglutamine-Induced Toxicity inInternational journal of molecular sciences · 2024
    Article
  14. Review
  15. IcarifilJournal of clinical medicine · 2024
    Article
  16. Review
  17. Emerging Role ofNutrients · 2024
    Review
  18. Article
  19. Erucin, an HInternational journal of molecular sciences · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Valerio CicconeDepartment of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-5374-9694
Eugenia PiragineDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.ORCID 0000-0001-6558-3065
Era GoricaDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
Valentina CitiDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
Lara TestaiDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.ORCID 0000-0003-2431-6248
Eleonora PagnottaResearch Centre for Cereal and Industrial Crops, CREA Council for Agricultural Research and Economics, Via di Corticella 133, 40134 Bologna, Italy.ORCID 0000-0002-9477-1724
Roberto MatteoResearch Centre for Cereal and Industrial Crops, CREA Council for Agricultural Research and Economics, Via di Corticella 133, 40134 Bologna, Italy.ORCID 0000-0001-8588-8798
Nicola PecchioniResearch Centre for Cereal and Industrial Crops, CREA Council for Agricultural Research and Economics, S.S. 673 Km 25,200, 71122 Foggia, Italy.
Rosangela MontanaroDepartment of Science, University of Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.
Lorenzo Di Cesare MannelliPharmacology and Toxicology Section, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Viale Gaetano Pieraccini, 6, 50139 Florence, Italy.ORCID 0000-0001-8374-4432
Carla GhelardiniPharmacology and Toxicology Section, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Viale Gaetano Pieraccini, 6, 50139 Florence, Italy.
Vincenzo BrancaleoneDepartment of Science, University of Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-0063-659X
Lucia MorbidelliDepartment of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0001-8148-7049
Vincenzo CalderoneDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
Alma MartelliDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.ORCID 0000-0002-2090-7107
University of Pisa · ITResearch Centre for Cereal and Industrial Crops · ITUniversity of Basilicata · ITUniversity of Florence · ITUniversity of Siena · ITCereal Research Centre · IT

Funding

Fondazione Umberto Veronesi, Milan (Italy) for Valerio Ciccone Post-doctoral Fellowship (2022).Ministry of Education, Universities and Research Bando per il finanziamento di Dimostratori Tecnologici DT (DT grant) Acronym: MEDICAMinistry of Education, Universities and Research Bando Proof-of-Concept SPARK PISA 2021" acronym "MELODIEMinistry of Education, Universities and Research Contratto per l'affidamento del servizio di consulenza farmacologica per la caratterizzazione cineticochimica del rilascio di acido solfidrico (H2S) da farmaci e molecole di origine naturale in soluzione, in vitro e in vivo e per la valutazione degli effeMinistry of Education, Universities and Research PON "Ricerca e Innovazione" 2014-2020-Azione II, by the COMETA research project "Colture autoctone mediterranee e loro valorizzazione con tecnologie avanzate di chimica verde" (Native Mediterranean crops and their enhancement with advanced green chemistryMinistry of Education, Universities and Research PRIN 2017XP72RF-Hydrogen Sulfide in the Vascular inflamm-Aging: role, therapeutic Opportu-nities and development of novel pharmacological tools for age-related cardiovascular diseases (SVAgO)
6 · The paper itself

Abstract

Vascular inflammation (VI) represents a pathological condition that progressively affects the integrity and functionality of the vascular wall, thus leading to endothelial dysfunction and the onset of several cardiovascular diseases. Therefore, the research of novel compounds able to prevent VI represents a compelling need. In this study, we tested erucin, the natural isothiocyanate H

Indexed as

Endothelium, VascularSignal TransductionAnimalsAnti-Inflammatory AgentsHumansHuman Umbilical Vein Endothelial CellsLipopolysaccharidesMiceNF-kappa BSulfidesThiocyanatesTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1Anti-Inflammatory AgentserucinLipopolysaccharidesNF-kappa BSulfidesThiocyanatesTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1endothelial dysfunctionEruca sativa Mill.erucinhydrogen sulfideisothiocyanatesvascular inflammation

Identifiers

PMID36555238
PMCPMC9778978
OpenAlexW4311960576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.