Evidence map›Paper›PMID 36555216›Full record

ArticleInternational journal of molecular sciences2022

Gold Nanosystems Covered with Doxorubicin/DNA Complexes: A Therapeutic Target for Prostate and Liver Cancer.

Rosa M Giráldez-Pérez, Elia Grueso, Antonio J Montero-Hidalgo, Raúl M Luque, José M Carnerero, Edyta Kuliszewska, Rafael Prado-Gotor

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rosa M Giráldez-PérezDepartment of Cell Biology, Physiology and Immunology, Faculty of Sciences, University of Cordoba, 14014 Cordoba, Spain.ORCID 0000-0002-9495-1047
Elia GruesoDepartment of Physical Chemistry, Faculty of Chemistry, University of Seville, 41012 Seville, Spain.ORCID 0000-0002-1397-6104
Antonio J Montero-HidalgoMaimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital (HURS), Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain.
Raúl M LuqueMaimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital (HURS), Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain.ORCID 0000-0002-7585-1913
José M CarnereroDepartment of Physical Chemistry, Faculty of Chemistry, University of Seville, 41012 Seville, Spain.ORCID 0000-0001-5118-6472
Edyta KuliszewskaChemtra, 47-300 Krapkowize, Poland.
Rafael Prado-GotorDepartment of Physical Chemistry, Faculty of Chemistry, University of Seville, 41012 Seville, Spain.ORCID 0000-0001-5959-9810
Universidad de Sevilla · ESSpanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition · ESUniversity of Córdoba · ES

Funding

Andalusian Research, Development and Innovation Plan (PAIDI) 2020 a 2021/FQM-386CIBERobn (CIBER is an initiative of Instituto de Salud Carlos III, Ministerio de Sanidad, Servicios Sociales e Igualdad, Spain)Spanish Ministry of Science, Innovation and Universities (PID2019-105564RB-I00; FPU18/02485)University of Seville, Spain VI PP Use of General Research Services PPI534/2020, PPI539/2020 and 2021/0000129
6 · The paper itself

Abstract

Different gold nanosystems covered with DNA and doxorubicin (Doxo) were designed and synthesized for cancer therapy, starting from Au@16-Ph-16 cationic nanoparticles and DNA-Doxo complexes prepared under saturation conditions. For the preparation of stable, biocompatible, and small-sized compacted Au@16-Ph-16/DNA-Doxo nanotransporters, the conditions for the DNA-Doxo compaction process induced by gold nanoparticles were first explored using fluorescence spectroscopy, circular dichroism and atomic force microscopy techniques. The reverse process, which is fundamental for Doxo liberation at the site of action, was found to occur at higher C

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMetal NanoparticlesCell Line, TumorDNADNA AdductsDoxorubicinGoldHumansMaleProstateDNADNA AdductsDoxorubicindoxorubicin-DNAGoldchemotherapyDNA compactiondoxorubicingemini surfactantsgold nanoparticles

Identifiers

PMID36555216
PMCPMC9779246
OpenAlexW4311957471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.