Evidence map›Paper›PMID 36555200›Full record

ArticleInternational journal of molecular sciences2022

Identification of

Qian Gong, Zhewei Hu, Qiao Jin, Yan Yan, Yan Liu, Jin He, Lenan Zhuang, Huanan Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qian GongDepartment of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Zhewei HuDepartment of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Qiao JinDepartment of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-4084-7068
Yan YanDepartment of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Yan LiuDepartment of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Jin HeInstitute of Genetics and Reproduction, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-8243-478X
Lenan ZhuangKey Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China.ORCID 0000-0001-9561-8396
Huanan WangDepartment of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0003-3162-2382
Zhejiang University · CNSir Run Run Shaw Hospital · CN

Funding

National Key Research and Development Program of China 2021YFA0805902National Natural Science Foundation of China 2019YFE0117400National Natural Science Foundation of China 32270884National Natural Science Foundation of China 81941003
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by pulmonary vascular remodeling and right heart enlargement the pathogenesis of PAH is complicated; no biologic-based therapy is available for the treatment of PAH, but recent studies suggest that inflammatory response and abnormal proliferation of pulmonary artery smooth muscle cells are the main pathogenic mechanism, while the role of immune-related long non-coding RNAs (lncRNAs) remains unclear. The aim of this study was to systematically analyze immune-related lncRNAs in PAH. Here, we downloaded a publicly available microarray data from PAH and control patients (GSE113439). A total of 243 up-regulated and 203 down-regulated differentially expressed genes (DEGs) were screened, and immune-related DEGs were further obtained from ImmPort. The immune-related lncRNAs were obtained by co-expression analysis of immune-related mRNAs. Then, immune-related lncRNAs-mRNAs network including 2 lncRNAs and 6 mRNAs was constructed which share regulatory miRNAs and have significant correlation. Among the lncRNA-mRNA pairs, one pair (

Indexed as

Pulmonary Arterial HypertensionRNA, Long NoncodingAnimalsBiomarkersComputational BiologyFamilial Primary Pulmonary HypertensionMiceRNA, MessengerBiomarkersRNA, Long NoncodingRNA, Messengerbioinformatics analysisimmune cell infiltrationnon-coding RNAspulmonary arterial hypertension

Identifiers

PMID36555200
PMCPMC9779127
OpenAlexW4311957482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.