Evidence map›Paper›PMID 36555192›Full record

ArticleInternational journal of molecular sciences2022

A Recombinant Genotype I Japanese Encephalitis Virus Expressing a

Chenxi Li, Xuan Chen, Jingbo Hu, Daoyuan Jiang, Demin Cai, Yanhua Li

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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  6. Antivirals and Vaccines.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chenxi LiCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Xuan ChenCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jingbo HuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Daoyuan JiangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Demin CaiCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0003-0500-5292
Yanhua LiCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-2141-5139
Yangzhou University · CN

Funding

High-level Scientific Research Foundation of Yangzhou University for the introduction of talent 5020/137012128National Natural Science Foundation of China 32202886Natural Science Foundation of Jiangsu Province, China BK20220576Natural Science Foundation of the Jiangsu Higher Education Institutions of China 1020220173State Key Laboratory of Veterinary Biotechnology Foundation Grant No. SKLVBF202105
6 · The paper itself

Abstract

Japanese encephalitis virus (JEV) is the major cause of viral encephalitis in humans throughout Asia. In the past twenty years, the emergence of the genotype I (GI) JEV as the dominant genotype in Asian countries has raised a significant threat to public health security. However, no clinically approved drug is available for the specific treatment of JEV infection, and the commercial vaccines derived from the genotype III JEV strains merely provided partial protection against the GI JEV. Thus, an easy-to-perform platform in high-throughput is urgently needed for the antiviral drug screening and assessment of neutralizing antibodies specific against the GI JEV. In this study, we established a reverse genetics system for the GI JEV strain (YZ-1) using a homologous recombination strategy. Using this reverse genetic system, a

Indexed as

CopepodaEncephalitis, JapaneseEncephalitis Virus, JapaneseAnimalsAntibodies, NeutralizingAntibodies, ViralAntiviral AgentsDrug Evaluation, PreclinicalGenotypeHumansLuciferasesAntibodies, NeutralizingAntibodies, ViralAntiviral AgentsLuciferasesantiviral drug screeninggaussia luciferasegenotype I Japanese encephalitis virusneutralization assayreporter virus

Identifiers

PMID36555192
PMCPMC9778660
OpenAlexW4311957670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.