Evidence map›Paper›PMID 36555189›Full record

ArticleInternational journal of molecular sciences2022

TRIAC Treatment Improves Impaired Brain Network Function and White Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice.

Jonathan Rochus Reinwald, Wolfgang Weber-Fahr, Alejandro Cosa-Linan, Robert Becker, Markus Sack, Claudia Falfan-Melgoza, Natalia Gass, Urs Braun, Christian Clemm von Hohenberg, Jiesi Chen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. MCT8 Deficiency in Infancy: Opportunities for Early Diagnosis and Screening.International journal of neonatal screening · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Jonathan Rochus ReinwaldResearch Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.
Wolfgang Weber-FahrResearch Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.
Alejandro Cosa-LinanResearch Group in Silico Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.
Robert BeckerResearch Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.
Markus SackResearch Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.
Claudia Falfan-MelgozaResearch Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.ORCID 0000-0003-1313-6436
Natalia GassResearch Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.ORCID 0000-0001-7654-0570
Urs BraunResearch Group Systems Neuroscience in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.
Christian Clemm von HohenbergResearch Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.
Jiesi ChenLeibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Germany.
Steffen MayerlDepartment of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
Thomas F MuenteDepartment of Neurology, University of Lübeck, 23538 Lübeck, Germany.
Heike HeuerLeibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Germany.ORCID 0000-0001-7094-6959
Alexander SartoriusResearch Group Translational Imaging, Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159 Mannheim, Germany.
Heidelberg University · DELeibniz Institute of Environmental Medicine · DEJohannes Gutenberg University Mainz · DEUniversity of Duisburg-Essen · DEUniversity of Lübeck · DE

Funding

Deutsche Forschungsgemeinschaft CRC/TR296 -P07, -P09, -P19Deutsche Forschungsgemeinschaft DFG EB187/8-1Deutsche Forschungsgemeinschaft DFG HE 3418/7-1Deutsche Forschungsgemeinschaft DFG SA 1869/11-2Deutsche Forschungsgemeinschaft DFG SA 1869/15-1Federal Ministry of Education and Research 01EW2010B NeuroMarKet
6 · The paper itself

Abstract

Dysfunctions of the thyroid hormone (TH) transporting monocarboxylate transporter MCT8 lead to a complex X-linked syndrome with abnormal serum TH concentrations and prominent neuropsychiatric symptoms (Allan-Herndon-Dudley syndrome, AHDS). The key features of AHDS are replicated in double knockout mice lacking MCT8 and organic anion transporting protein OATP1C1 (

Indexed as

SymportersWhite MatterX-Linked Intellectual DisabilityAnimalsMaleMiceMice, KnockoutMonocarboxylic Acid TransportersMuscle HypotoniaMuscular AtrophyThyroid HormonesTriiodothyronine3,3',5-triiodothyroacetic acidMonocarboxylic Acid TransportersSymportersThyroid HormonesTriiodothyronineAllan-Herndon-Dudley-syndromebrain networkgraph analysisSlc16a2Slco1c1T3T4thyroid hormonevoxel-based morphometry

Identifiers

PMID36555189
PMCPMC9779161
OpenAlexW4311952982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.