Evidence map›Paper›PMID 36555104›Full record

ArticleInternational journal of molecular sciences2022

Novel p.G250A Mutation Associated with Chronic Pancreatitis Highlights Misfolding-Prone Region in Carboxypeptidase A1 (CPA1).

Máté Sándor, Franziska G Thiel, Margit Schmid, Alexandra Demcsák, Nataly C Morales Granda, Balázs Csaba Németh, Sandor Vajda, André Hoerning, Miklós Sahin-Tóth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. MisfoldingAmerican journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  4. Article
  5. Zoological research · 2025
    Article
  6. Article
  7. Article
  8. Misfolding PRSS1 variant p.Ala61Val in a case of suspected intrauterine pancreatitis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2025
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Máté SándorDepartment of Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA.
Franziska G ThielDepartment of Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-6322-9222
Margit SchmidClinic for Children and Adolescent Medicine, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Alexandra DemcsákDepartment of Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5391-6931
Nataly C Morales GrandaDepartment of Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA.
Balázs Csaba NémethDepartment of Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-5338-7577
Sandor VajdaDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.ORCID 0000-0003-1540-8220
André HoerningClinic for Children and Adolescent Medicine, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.ORCID 0000-0001-6241-7168
Miklós Sahin-TóthDepartment of Surgery, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-4513-9922
University of California, Los Angeles · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEBoston University · US

Funding

Analysis and Prediction of Molecular InteractionsR35GM118078 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SANDOR VAJDA · 2016 to 2026
$6.5M
Molecular Pathomechanism of Hereditary PancreatitisR01DK058088 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAHIN-TOTH, MIKLOS · 2001 to 2019
$5.3M
A MULTISTAGE APPROACH TO PROTEIN-PROTEIN DOCKINGR01GM061867 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI VAJDA, SANDOR · 2000 to 2016
$4.0M
NIDDK NIH HHS DK058088NIDDK NIH HHS R01 DK058088NIGMS NIH HHS R01 GM061867NIGMS NIH HHS R35 GM118078NIGMS NIH HHS R35GM118078
6 · The paper itself

Abstract

Inborn mutations in the digestive protease carboxypeptidase A1 (CPA1) gene may be associated with hereditary and idiopathic chronic pancreatitis (CP). Pathogenic mutations, such as p.N256K, cause intracellular retention and reduced secretion of CPA1, accompanied by endoplasmic reticulum (ER) stress, suggesting that mutation-induced misfolding underlies the phenotype. Here, we report the novel p.G250A

Indexed as

Carboxypeptidases AGenetic Predisposition to DiseasePancreatitis, ChronicHumansMutationPhenotypeCarboxypeptidases Acarboxypeptidaseendoplasmic reticulum stressgenetic riskmisfoldingpancreatitis

Identifiers

PMID36555104
PMCPMC9779553
OpenAlexW4311716764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.