Evidence map›Paper›PMID 36555003›Full record

ReviewInsects2022

Chemical Control of Mosquitoes and the Pesticide Treadmill: A Case for Photosensitive Insecticides as Larvicides.

Cole J Meier, Matthew F Rouhier, Julián F Hillyer

Open access · goldAbstract readReview
In one paragraph

Review in Insects, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Mechanisms of carbamate resistance in the malaria vector:Parasite epidemiology and control · 2026
    Review
  5. Article
  6. Article
  7. Frontiers in microbiology · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Bioactive profiling, larvicidal and pupicidal activities ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Article
  14. Article
  15. Article
  16. Making scents of mosquito repellents.Trends in parasitology · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Isolation of a NovelJournal of fungi (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Cole J MeierDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0002-7145-6246
Matthew F RouhierDepartment of Chemistry, Kenyon College, Gambier, OH 43022, USA.ORCID 0000-0002-3872-4958
Julián F HillyerDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.ORCID 0000-0002-3178-0201
Vanderbilt University · USKenyon College · US

Funding

Vanderbilt University Institutional Funds
6 · The paper itself

Abstract

Insecticides reduce the spread of mosquito-borne disease. Over the past century, mosquito control has mostly relied on neurotoxic chemicals-such as pyrethroids, neonicotinoids, chlorinated hydrocarbons, carbamates and organophosphates-that target adults. However, their persistent use has selected for insecticide resistance. This has led to the application of progressively higher amounts of insecticides-known as the pesticide treadmill-and negative consequences for ecosystems. Comparatively less attention has been paid to larvae, even though larval death eliminates a mosquito's potential to transmit disease and reproduce. Larvae have been targeted by source reduction, biological control, growth regulators and neurotoxins, but hurdles remain. Here, we review methods of mosquito control and argue that photoactive molecules that target larvae-called photosensitive insecticides or PSIs-are an environmentally friendly addition to our mosquitocidal arsenal. PSIs are ingested by larvae and produce reactive oxygen species (ROS) when activated by light. ROS then damage macromolecules resulting in larval death. PSIs are degraded by light, eliminating environmental accumulation. Moreover, PSIs only harm small translucent organisms, and their broad mechanism of action that relies on oxidative damage means that resistance is less likely to evolve. Therefore, PSIs are a promising alternative for controlling mosquitoes in an environmentally sustainable manner.

Indexed as

CulicidaeDipterainsect controlinsecticide resistancepest managementphotoactivephotodynamicreactive oxygen species

Identifiers

PMID36555003
PMCPMC9783766
OpenAlexW4310154668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.