Evidence map›Paper›PMID 36554987›Full record

ArticleInsects2022

Study of the Repellent Activity of 60 Essential Oils and Their Main Constituents against

Weifeng Wu, Yu Yang, Yingmiao Feng, Xiaofei Ren, Yuling Li, Wenjiao Li, Jietong Huang, Lingjia Kong, Xiaole Chen, Zhongze Lin and 5 more

Abstract read
In one paragraph

Article in Insects, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Weifeng WuSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
Yu YangSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
Yingmiao FengThe Third Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Xiaofei RenSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
Yuling LiSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
Wenjiao LiSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
Jietong HuangSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
Lingjia KongSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
Xiaole ChenSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
Zhongze LinFaculty of Southern Medicine, Guangdong Jiangmen Chinese Medicine College, Jiangmen 529000, China.
Xiaohui HouSchool of Preclinical Medicine, Zunyi Medical University, Zunyi 563003, China.
Longlai ZhangMHOME (Guangzhou) Industrial Co., Ltd., Guangzhou 510700, China.
Yajie ChenSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.ORCID 0000-0001-6567-0396
Zhaojun ShengSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.ORCID 0000-0002-6406-704X
Weiqian HongSchool of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.

Funding

Jiangmen Science and Technology Project of Basic and Theoretical Science Research 2021030101400004873Project of Innovative and Entrepreneurship for College Students in Wuyi University 202111349298Special Fund Project of Science and Technology Innovation Strategy in Guangdong Province Jiangke(2018)352Start-up Foundation for High-level Talents of Wuyi University 2017RC04Wuyi University-Hong Kong and Macao Joint Research Fund 2021WGALH10
6 · The paper itself

Abstract

Mosquitoes are one of the most important disease vectors from a medical viewpoint in that they transmit several diseases such as malaria, filariasis, yellow and Dengue fever. Mosquito vector control and personal protection from mosquito bites are currently the most efficient ways to prevent these diseases. Several synthetic repellents such as DEET, ethyl butylacetylaminopropionate (IR3535) and 1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine) (Picaridin), have been widely used to prevent humans from receiving mosquito bites. However, the use of synthetic repellents has raised several environment and health concerns. Therefore, essential oils (EOs) as natural alternatives receive our attention. In order to discover highly effective mosquito repellents from natural sources, the repellent activity of 60 commercial EOs against Ae. albopictus was screened in this study. Eight EOs including cinnamon, marjoram, lemongrass, bay, chamomile, jasmine, peppermint2, and thyme, showed a suitable repellent rate (>40%) at the tested dose of 10 μg/cm2. Then, their main constituents were analyzed by GC-MS, and the active constituents were identified. The most active compounds including cinnamaldehyde, citral and terpinen-4-ol, exhibited an 82%, 65% and 60% repellent rate, respectively. Moreover, the nanoemulsions of the three active compounds were prepared and characterized. In the arm-in-cage assay, the protection times of the nanoemulsions of cinnamaldehyde and citral were significantly extended compared with their normal solutions. This study provides several lead compounds to develop new mosquito repellents, and it suggests that nanoemulsification is an effective method for improving the duration of the activity of natural repellents.

Indexed as

Aedes albopictusessential oilnanoemulsionrepellent

Identifiers

PMID36554987
PMCPMC9782114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.