Trial reportInternational journal of environmental research and public health2022
Effect of Fluoride Varnish in Preventing Dental Caries of First Permanent Molars: A 24-Month Cluster Randomized Controlled Trial.
Trial report in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The Effectiveness of Topical Fluorides in Preventing Dental Caries in Children and Adolescents: A Systematic Review and Meta-Analysis.Oral health & preventive dentistry · 2026Pooled it
- Impact of fluoride varnish and oral health education on caries increment and dental plaque microbiota among children with early mixed dentition: a three-armed 24-month randomized controlled trial.Microbiology spectrum · 2025Trial
- Fissure Sealants or Fluoride Varnish? A Randomized Pragmatic Split-Mouth Trial.Journal of dental research · 2024Trial
- Cost-effectiveness and cost-benefit analyses of fluoride varnish for caries prevention in Guangxi, China.BMC oral health · 2024Trial
- Oral Health Promotion Among Students in Special Education Schools: Protocol for a Multicity Cluster Randomized Controlled Trial.JMIR research protocols · 2026Article
- Comparative assessment of the long-term effects of 5% sodium fluoride varnishes with and without tricalcium phosphate on enamel microhardness of primary teeth: AnDental research journal · 2026Article
- Review
- Protocol for a Cluster-Randomized Controlled Trial on the Effectiveness of Fluoride Varnish in Preventing Dental Caries Among Rural School Children in Namkum, Ranchi.Journal of pharmacy & bioallied sciences · 2025Article
- Article
- Regional Epidemiological Study on the Dental Status of the First Permanent Molar in Romanian Schoolchildren.Dentistry journal · 2025Article
- Eruption and caries status of first permanent molars in children aged 6-7 years in Shijingshan District, Beijing, China.BMC oral health · 2024Article
- A Time Study Analysis of Fluoride Varnish Application in Pediatric Well Visits to Address Health Disparities among Children.Journal of applied research on industrial engineering · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCaries is a prevalent health problem. This study evaluated the effect of fluoride varnish in preventing dental caries of first permanent molars.
methodsThe study was designed as a stratified cluster randomized controlled trial, with classes as the unit of randomization. Classes stratified by district were followed for 24 months. All eligible children of the selected classes were included for the trial. The children in the test group were biannually applied fluoride varnish. The outcomes were measured at an individual level.
resultsIn total, 107 classes (51 in the test group, 56 in the control group) were recruited for the trial. Of the 5397 participants, 5005 children (2385 in the test group, 2620 in the control group) completed the study. At the 24-month follow-up, the mean decayed and filled surface increment of the first permanent molars of the children in the test group was significantly lower than that of the children in the control group (0.38 versus 0.61). The caries incidence of the first permanent molars in the test group was 17.0%, while that of the control group was 23.7%, with a PF of 28.3%.
conclusionsSemi-annual application of fluoride varnish is effective in reducing the caries increments of first permanent molars.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.