Evidence map›Paper›PMID 36553634›Full record

ArticleGenes2022

Potential Cytoprotective and Regulatory Effects of Ergothioneine on Gene Expression of Proteins Involved in Erythroid Adaptation Mechanisms and Redox Pathways in K562 Cells.

Victoria Simões Bernardo, Flaviene Felix Torres, Carla Peres de Paula, João Pedro Maia de Oliveira da Silva, Eduardo Alves de Almeida, Anderson Ferreira da Cunha, Danilo Grünig Humberto da Silva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Victoria Simões BernardoDepartment of Biology, Universidade Estadual Paulista (UNESP), José do Rio Preto 15054-000, SP, Brazil.ORCID 0000-0003-3353-9056
Flaviene Felix TorresDepartment of Biology, Universidade Estadual Paulista (UNESP), José do Rio Preto 15054-000, SP, Brazil.
Carla Peres de PaulaDepartment of Genetics and Evolution, Universidade Federal de São Carlos (UFSCar), São Carlos 13565-905, SP, Brazil.
João Pedro Maia de Oliveira da SilvaDepartment of Genetics and Evolution, Universidade Federal de São Carlos (UFSCar), São Carlos 13565-905, SP, Brazil.
Eduardo Alves de AlmeidaDepartment of Natural Sciences, Fundação Universidade Regional de Blumenau (FURB), Blumenau 89030-000, SC, Brazil.
Anderson Ferreira da CunhaDepartment of Genetics and Evolution, Universidade Federal de São Carlos (UFSCar), São Carlos 13565-905, SP, Brazil.
Danilo Grünig Humberto da SilvaCampus de Três Lagoas, Universidade Federal de Mato Grosso do Sul (CPTL/UFMS), Três Lagoas 79613-000, MS, Brazil.
Universidade Federal de São Carlos · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade Federal de Mato Grosso do Sul · BRUniversidade Regional de Blumenau · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to establish the importance of ergothioneine (ERT) in the erythroid adaptation mechanisms by appraising the expression levels of redox-related genes associated with the PI3K/AKT/FoxO3 and Nrf2-ARE pathways using K562 cells induced to erythroid differentiation and H

Indexed as

ErgothioneineGene ExpressionHumansHydrogen PeroxideK562 CellsKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Oxidation-ReductionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionErgothioneineHydrogen PeroxideKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktantioxidantsproteasomeredox adaptationtherapeutic agent

Identifiers

PMID36553634
PMCPMC9778224
OpenAlexW4311612035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.