Evidence map›Paper›PMID 36553550›Full record

ArticleGenes2022

In Vitro Analysis of Biological Activity of Circulating Cell-Free DNA Isolated from Blood Plasma of Schizophrenic Patients and Healthy Controls-Part 2: Adaptive Response.

Svetlana V Kostyuk, Elizaveta S Ershova, Andrey V Martynov, Andrey V Artyushin, Lev N Porokhovnik, Elena M Malinovskaya, Elizaveta M Jestkova, Natalia V Zakharova, George P Kostyuk, Vera L Izhevskaia and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Svetlana V KostyukFederal State Budgetary Scientific Institution, Research Centre for Medical Genetics, 115522 Moscow, Russia.
Elizaveta S ErshovaFederal State Budgetary Scientific Institution, Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0003-1206-5832
Andrey V MartynovFederal State Budgetary Scientific Institution, Research Centre for Medical Genetics, 115522 Moscow, Russia.
Andrey V ArtyushinFederal State Budgetary Scientific Institution, Research Centre for Medical Genetics, 115522 Moscow, Russia.
Lev N PorokhovnikFederal State Budgetary Scientific Institution, Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0002-3664-6685
Elena M MalinovskayaFederal State Budgetary Scientific Institution, Research Centre for Medical Genetics, 115522 Moscow, Russia.
Elizaveta M JestkovaFederal State Budgetary Scientific Institution, Research Centre for Medical Genetics, 115522 Moscow, Russia.
Natalia V ZakharovaN. A. Alekseev Clinical Psychiatric Hospital No 1, Moscow Healthcare Department, 117152 Moscow, Russia.
George P KostyukN. A. Alekseev Clinical Psychiatric Hospital No 1, Moscow Healthcare Department, 117152 Moscow, Russia.ORCID 0000-0002-3073-6305
Vera L IzhevskaiaFederal State Budgetary Scientific Institution, Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0002-7246-5144
Sergey I KutsevFederal State Budgetary Scientific Institution, Research Centre for Medical Genetics, 115522 Moscow, Russia.
Natalia N VeikoFederal State Budgetary Scientific Institution, Research Centre for Medical Genetics, 115522 Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidized in vitro genomic DNA (gDNA) is known to launch an adaptive response in human cell cultures. The cfDNA extracted from the plasma of schizophrenic patients (sz-cfDNA) and healthy controls (hc-cfDNA) contains increased amounts of 8-oxodG, a DNA-oxidation marker. The aim of the research was answering a question: can the human cfDNA isolated from blood plasma stimulate the adaptive response in human cells? In vitro responses of ten human skin fibroblasts (HSFs) and four peripheral blood mononuclear cell (PBMC) lines after 1-24 h of incubation with sz-cfDNA, gDNA and hc-cfDNA containing different amounts of 8-oxodG were examined. Expressions of RNA of eight genes (

Indexed as

Cell-Free Nucleic AcidsSchizophrenia8-Hydroxy-2'-DeoxyguanosineAntioxidantsbcl-2-Associated X ProteinDNAHumansLeukocytes, MononuclearNF-E2-Related Factor 2PlasmaReactive Oxygen SpeciesSuperoxide Dismutase-18-Hydroxy-2'-DeoxyguanosineAntioxidantsbcl-2-Associated X ProteinCell-Free Nucleic AcidsDNANF-E2-Related Factor 2Reactive Oxygen SpeciesSuperoxide Dismutase-1adaptive responseBRCA1cell-free DNAHIF1ANOX4NRF2schizophreniaSOD1γH2AX

Identifiers

PMID36553550
PMCPMC9777734

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.