Evidence map›Paper›PMID 36553518›Full record

ArticleGenes2022

Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico.

Humberto García-Ortiz, Francisco Barajas-Olmos, Cecilia Contreras-Cubas, Austin W Reynolds, Marlen Flores-Huacuja, Meradeth Snow, Jazmín Ramos-Madrigal, Elvia Mendoza-Caamal, Paulina Baca, Tomás A López-Escobar and 17 more

Abstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Humberto García-OrtizInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.ORCID 0000-0002-0453-980X
Francisco Barajas-OlmosInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.ORCID 0000-0001-5064-6203
Cecilia Contreras-CubasInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.
Austin W ReynoldsDepartment of Anthropology, Baylor University, Waco, TX 76706, USA.ORCID 0000-0002-7154-1379
Marlen Flores-HuacujaInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.
Meradeth SnowDepartment of Anthropology, University of Montana, Missoula, MT 59812, USA.
Jazmín Ramos-MadrigalSection for Evolutionary Genomics, The GLOBE Institute, The University of Copenhagen, Øster Farimagsgade 5A, 1352 Copenhagen, Denmark.
Elvia Mendoza-CaamalInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.
Paulina BacaInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.
Tomás A López-EscobarInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.
Deborah A BolnickDepartment of Anthropology and Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269-3003, USA.
Silvia Esperanza Flores-MartínezDivisión de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Mexico.
Rocio Ortiz-LopezTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud and Insitute for Obesity Research, Monterrey 64700, Mexico.
Aleksandar David KosticJoslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA.
José Rafael Villafan-BernalInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.ORCID 0000-0002-6135-4270
Carlos Galaviz-HernándezInstituto Politécnico Nacional, CIIDIR-Durango, Durango 34220, Mexico.
Federico Centeno-CruzInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.ORCID 0000-0002-3512-4519
Alejandra Guadalupe García-ZapiénDepartamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara 44430, Mexico.
Tulia Monge-CázaresInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.
Blanca Patricia Lazalde-RamosUnidad Académica de Ciencias Químicas, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico.ORCID 0000-0002-1995-1696
Francisco Loeza-BecerraUniversidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mexico.
María Del Carmen Abrahantes-PérezInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.ORCID 0000-0002-1312-3988
Héctor Rangel-VillalobosInstituto de Investigación en Genética Molecular, Universidad de Guadalajara Ocotlán, Ocotlán 44100, Mexico.
Martha Sosa-MacíasInstituto Politécnico Nacional, CIIDIR-Durango, Durango 34220, Mexico.
Augusto Rojas-MartínezTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud and Insitute for Obesity Research, Monterrey 64700, Mexico.ORCID 0000-0003-3765-6778
Angélica Martínez-HernándezInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.
Lorena OrozcoInstituto Nacional de Medicina Genómica, Tlalpan, Mexico City 14610, Mexico.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
NIDDK NIH HHS P30 DK036836
6 · The paper itself

Abstract

Few studies have addressed how selective pressures have shaped the genetic structure of the current Native American populations, and they have mostly limited their inferences to admixed Latin American populations. Here, we searched for local adaptation signals, based on integrated haplotype scores and population branch statistics, in 325 Mexican Indigenous individuals with at least 99% Native American ancestry from five previously defined geographical regions. Although each region exhibited its own local adaptation profile, only

Indexed as

Adaptation, PhysiologicalAmerican Indian or Alaska NativeHispanic or LatinoHumansMexicoRacial GroupsAJAP1gut microbiomelocal adaptationNative American populationsPPARG

Identifiers

PMID36553518
PMCPMC9778281

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.