ArticleChildren (Basel, Switzerland)2022
Oral Immunotherapy for Children with Cow's Milk Allergy: A Practical Approach.
Article in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Cow's milk protein allergy in infants: Clinical presentations and outcomes.World journal of clinical pediatrics · 2026Article
- Oral Immunotherapy Should Play a Key Role in Preschool Food Allergy Management.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Review
- Nutritional Strategies for the Prevention and Management of Cow's Milk Allergy in the Pediatric Age.Nutrients · 2023Review
- Molecular Mechanism and Clinical Effects of Probiotics in the Management of Cow's Milk Protein Allergy.International journal of molecular sciences · 2023Review
- Mediterranean Milk Ladder: Integrating a Healthy Eating Plan While Reintroducing Cow's Milk.Children (Basel, Switzerland) · 2023Article
- Molecular Allergy Diagnostics in Children with Cow's Milk Allergy: Prediction of Oral Food Challenge Response in Clinical Practice.Journal of immunology research · 2023Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
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Abstract
Cow milk allergy (CMA) is a prevalent disease in childhood. Natural history is usually favorable as CMA can disappear by school age in many subjects. Diagnosis corresponds to treatment, as an elimination diet is a solution. However, cow's milk (CM) is real food, hardly replaceable. Thus, CM reintroduction represents a demanding challenge in clinical practice. The induction of CM tolerance could be achievable using oral immunotherapy (OIT), such as the administration of increasing milk quantities until reaching tolerance. However, the OIT schedule and procedure need to be better standardized, and performance may vary widely. Therefore, the present study reports the practical experience of a third-level pediatric allergy center in managing children with CMA and submitting them to OIT. OFC and OIT are relatively safe procedures as the reaction rate is low. Almost two-thirds of the OIT subjects tolerated CM. Reactions were associated with high IgE levels. Therefore, the present experience, developed by a qualified center, may suggest and propose a practical approach for managing children with CMA. After the initial workup, including a thorough history, physical examination, and laboratory tests, OFC and, when indicated, OIT could be performed in most children with CMA.
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