Evidence map›Paper›PMID 36553228›Full record

ArticleDiagnostics (Basel, Switzerland)2022

The Pitfall of Ganglioneuroblastoma-Nodular Diagnosis: Clinical and Imaging Considerations over a Rare Bifocal Sporadic Case.

Claudio Montante, Francesco Fabozzi, Maria Felicia Villani, Maria Luisa D'Andrea, Alessandra Stracuzzi, Gian Luigi Natali, Giada Del Baldo, Francesca Del Bufalo, Maria Carmen Garganese, Annalisa Serra and 6 more

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Claudio MontanteDepartment of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Francesco FabozziDepartment of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-3906-4410
Maria Felicia VillaniDepartment of Imaging, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Maria Luisa D'AndreaDepartment of Imaging, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Alessandra StracuzziDepartment of Pathology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Gian Luigi NataliDepartment of Imaging, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Giada Del BaldoDepartment of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0003-3540-4331
Francesca Del BufaloDepartment of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0001-9643-3465
Maria Carmen GarganeseDepartment of Imaging, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Annalisa SerraDepartment of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Paolo TomàDepartment of Imaging, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-0158-4760
Rita AlaggioDepartment of Pathology, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Sabina VennariniPediatric Radiotherapy Unit, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy.
Giovanna Stefania ColafatiDepartment of Imaging, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-1142-4904
Angela MastronuzziDepartment of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-4408-2373
Maria Antonietta De IorisDepartment of Onco-Hematology, Cell and Gene Therapies, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-2113-4505

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastic tumors (NTs) represent the most common extracranial neoplasm occurring in childhood. Although ganglioneuroblastoma intermixed (GNBI) and ganglioneuroma (GN) are classified as very low-risk tumors, neuroblastoma (NB) and ganglioneuroblastoma-nodular (GNBN) may represent a serious risk to survival. Unfortunately, areas of GNBI and GNBN can coexist in the same mass, leading to incorrect risk staging when only biopsy is performed. Herein, we describe a case of multifocal NT (thoracic and abdominal localization) occurring in a 4-year-old male. Different histological subtypes, namely GNBI and GNBN, were revealed in the two lesions. We focus on the difficulties of proper diagnosis and risk stratification, underlining the usefulness of several diagnostic tools for appropriate management and therapeutic choices.

Indexed as

ganglioneuroblastomamultifocal tumorneuroblastoma

Identifiers

PMID36553228
PMCPMC9777706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.