Evidence map›Paper›PMID 36553120›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Proposal to Improve the Image Quality of Short-Acquisition Time-Dedicated Breast Positron Emission Tomography Using the Pix2pix Generative Adversarial Network.

Tomoyuki Fujioka, Yoko Satoh, Tomoki Imokawa, Mio Mori, Emi Yamaga, Kanae Takahashi, Kazunori Kubota, Hiroshi Onishi, Ukihide Tateishi

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The Evolution and Clinical Impact of Deep Learning Technologies in Breast MRI.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Tomoyuki FujiokaDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.ORCID 0000-0002-7141-8901
Yoko SatohYamanashi PET Imaging Clinic, Chuo City 409-3821, Japan.ORCID 0000-0002-0188-0906
Tomoki ImokawaDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Mio MoriDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.ORCID 0000-0002-6107-4519
Emi YamagaDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Kanae TakahashiDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Kazunori KubotaDepartment of Radiology, Dokkyo Medical University Saitama Medical Center, Koshigaya 343-8555, Japan.ORCID 0000-0002-3240-4910
Hiroshi OnishiDepartment of Radiology, University of Yamanashi, Chuo City 409-3898, Japan.ORCID 0000-0002-3512-1166
Ukihide TateishiDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Tokyo Medical and Dental University · JPSocial Insurance Saitama Chuo Hospital · JPUniversity of Yamanashi · JPUniversity of Yamanashi Hospital · JP

Funding

Japan Society for the Promotion of Science KAKENHI Grant Number 21K15800
6 · The paper itself

Abstract

This study aimed to evaluate the ability of the pix2pix generative adversarial network (GAN) to improve the image quality of low-count dedicated breast positron emission tomography (dbPET). Pairs of full- and low-count dbPET images were collected from 49 breasts. An image synthesis model was constructed using pix2pix GAN for each acquisition time with training (3776 pairs from 16 breasts) and validation data (1652 pairs from 7 breasts). Test data included dbPET images synthesized by our model from 26 breasts with short acquisition times. Two breast radiologists visually compared the overall image quality of the original and synthesized images derived from the short-acquisition time data (scores of 1−5). Further quantitative evaluation was performed using a peak signal-to-noise ratio (PSNR) and structural similarity (SSIM). In the visual evaluation, both readers revealed an average score of >3 for all images. The quantitative evaluation revealed significantly higher SSIM (p < 0.01) and PSNR (p < 0.01) for 26 s synthetic images and higher PSNR for 52 s images (p < 0.01) than for the original images. Our model improved the quality of low-count time dbPET synthetic images, with a more significant effect on images with lower counts.

Indexed as

artificial intelligencebreast cancerdedicated breast positron emission tomographygenerative adversarial networkimage synthesis

Identifiers

PMID36553120
PMCPMC9777139
OpenAlexW4312126576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.